Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10006
Official Symbol:ABI1
Other Aliases:ABI-1|E3B1|NAP1BP|SSH3BP|SSH3BP1
See related:HGNC:11320|MIM:603050|HPRD:04336
Chromosome:10
Location:10p11.2
Gene Description:abl-interactor 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0232
ORGANISM:human
Entrez Gene ID:10006
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11308CBCerebellum37.761539459228555.3139457702637
11308CTXCerebral cortex100.0100.0
11308HIPHippocampal region100.0100.0
11308HPFHippocampal formation100.0100.0
11308HYHypothalamus57.618831634521550.581657409668
11308LSXLateral septal complex64.165122985839857.4167556762695
11308MBMidbrain46.664489746093843.7863502502441
11308MYMedulla40.629398345947345.0927734375
11308OLFOlfactory bulb95.5804214477539100.0
11308PPons46.566173553466849.299072265625
11308PALPallidum56.749851226806653.3985977172852
11308RHPRetrohippocampal region100.0100.0
11308sAMYStriatum-like amygdalar nuclei48.60638809204141.4545822143555
11308STRStriatum69.373085021972756.229679107666
11308STRdStriatum dorsal region70.758193969726656.481258392334
11308STRvStriatum ventral region74.942489624023460.7663726806641
11308THThalamus67.125022888183662.6054077148438
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10006GO:0005625TASComponentsoluble fraction
10006GO:0005634IEAComponentnucleus
10006GO:0005783TASComponentendoplasmic reticulum
10006GO:0005829TASComponentcytosol
10006GO:0005856IEAComponentcytoskeleton
10006GO:0007169TASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
10006GO:0008092TASFunctioncytoskeletal protein binding
10006GO:0008285TASProcessnegative regulation of cell proliferation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-55740NP_001008493.1enabled homolog isoform aHPRD12360
-54869NP_060199.2epidermal growth factor receptor pathway substrate 8-like protein 1 isoform bHPRD13276
BAB55675.110787NP_038464.1NCK-associated protein 1 isoform 1BIND194700
NP_005461.1--AblHPRD04336
NP_005461.1--eps8HPRD04336
NP_005461.1--Alpha 1 spectrinHPRD04336
NP_005461.151199NP_065972.2ninein isoform 2HPRD09785
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10006IPR012849Abi_HHRAbl-interactor HHR
10006IPR000108Neu_cyt_fact_2Neutrophil cytosol factor 2
10006IPR000694PRO_richProline-rich region
10006IPR001452SH3Src homology-3
10006IPR011511SH3_2Variant SH3
10006IPR000727T_SNARETarget SNARE coiled-coil region
10006IPR006077Vinculin/cateninVinculin/alpha-catenin
10006ABI1_HUMANQ8IZP0IPR012849Abi_HHRAbl-interactor HHR
10006ABI1_HUMANQ8IZP0IPR003980H3_rcptHistamine H3 receptor
10006ABI1_HUMANQ8IZP0IPR000108Neu_cyt_fact_2Neutrophil cytosol factor 2
10006ABI1_HUMANQ8IZP0IPR000694PRO_richProline-rich region
10006ABI1_HUMANQ8IZP0IPR001452SH3Src homology-3
10006ABI1_HUMANQ8IZP0IPR011511SH3_2Variant SH3
10006ABI1_HUMANQ8IZP0IPR000727T_SNARETarget SNARE coiled-coil region
10006ABI1_HUMANQ8IZP0IPR006077Vinculin/cateninVinculin/alpha-catenin

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