Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10008
Official Symbol:KCNE3
Other Aliases:DKFZp781H21101|HOKPP|MGC102685|MGC129924|MiRP2
See related:HGNC:6243|MIM:604433|HPRD:07256
Chromosome:11
Location:11q13-q14
Gene Description:potassium voltage-gated channel, Isk-related family, member 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0286
ORGANISM:human
Entrez Gene ID:10008
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.62
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
57442CBCerebellum5.590370655059814.8957941532135
57442CTXCerebral cortex4.308467507362372.95427423715591
57442HIPHippocampal region10.89825701713564.41230380535126
57442HPFHippocampal formation9.085757732391364.96282088756561
57442HYHypothalamus1.291515439748760.809629827737808
57442LSXLateral septal complex2.180324107408522.80101462826133
57442MBMidbrain1.930795729160311.53050667047501
57442MYMedulla2.896156191825873.17079222202301
57442OLFOlfactory bulb6.47801256179813.45557975769043
57442PPons3.699067234992983.09473049640656
57442PALPallidum0.2977709621191020.232468001544476
57442RHPRetrohippocampal region6.149018079042435.04093803465366
57442sAMYStriatum-like amygdalar nuclei2.253166943788531.33204528689384
57442STRStriatum0.9933363199234010.68466954678297
57442STRdStriatum dorsal region0.1753657534718510.114562094211578
57442STRvStriatum ventral region3.08042582869531.73897963762283
57442THThalamus1.421765536069870.837414056062698
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10008GO:0005249IEAFunctionvoltage-gated potassium channel activity
10008GO:0006811IEAProcession transport
10008GO:0006813IEAProcesspotassium ion transport
10008GO:0008076NRComponentvoltage-gated potassium channel complex
10008GO:0016020IEAComponentmembrane
10008GO:0016021IEAComponentintegral to membrane
10008GO:0030955IEAFunctionpotassium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10008KCNE3_HUMANQ9Y6H6IPR000369ISK_ChannelSlow voltage-gated potassium channel
10008KCNE3_HUMANQ9Y6H6IPR005426KCNE_beta3KCNE voltage-gated K+ channel beta-3 subunit

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