Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10019
Official Symbol:LNK
Other Aliases:-
See related:MIM:605093|HPRD:05480
Chromosome:12
Location:12q24
Gene Description:lymphocyte adaptor protein
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0356
ORGANISM:human
Entrez Gene ID:10019
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.74
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16923CBCerebellum11.872984528541612.2132943868637
16923CTXCerebral cortex35.248840451240529.9669837355614
16923HIPHippocampal region48.526561260223453.4173989295959
16923HPFHippocampal formation42.337486267089842.7231585979462
16923HYHypothalamus14.727700173854812.4760349988937
16923LSXLateral septal complex5.783678829669955.88574153184891
16923MBMidbrain16.571960330009516.5332931280136
16923MYMedulla21.583891481161129.6852745115757
16923OLFOlfactory bulb35.350270748138430.7536721229553
16923PPons21.142620205879226.2334379553795
16923PALPallidum14.810095250606515.6733435988426
16923RHPRetrohippocampal region32.895880103111326.0883509516716
16923sAMYStriatum-like amygdalar nuclei20.628773093223618.1747192144394
16923STRStriatum8.370798274874697.33331273496151
16923STRdStriatum dorsal region4.198842138051994.18153524398804
16923STRvStriatum ventral region16.252881139516810.6871299296618
16923THThalamus20.633477926254316.2488610744476
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10019GO:0007242IEAProcessintracellular signaling cascade
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_005466.1--LBP7HPRD05480
NP_005466.1--LBP8HPRD05480
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10019LNK_HUMANQ9UQQ2IPR001849PHPleckstrin-like
10019LNK_HUMANQ9UQQ2IPR013625PTBTensin phosphotyrosine-binding domain
10019LNK_HUMANQ9UQQ2IPR000980SH2SH2 motif

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