Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10076
Official Symbol:PTPRU
Other Aliases:FLJ37530|FMI|GLEPP1|PCP-2|PTP|PTP-J|PTP-PI|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|hPTP-J
See related:HGNC:9683|MIM:602454|HPRD:03908
Chromosome:1
Location:1p35.3-p35.1
Gene Description:protein tyrosine phosphatase, receptor type, U
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0377
ORGANISM:human
Entrez Gene ID:10076
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.5 :: -1.6 :: -1.6 :: -2.2 :: -2.3
KARG Evidence 2
KARG ID:EVIM0445
ORGANISM:human
Entrez Gene ID:10076
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.2 :: -1.2 :: -1.7 :: -4.8 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19273CBCerebellum2.025852799415592.20163142681122
19273CTXCerebral cortex16.566412448883112.6222834587097
19273HIPHippocampal region14.085921764373820.6665740013123
19273HPFHippocampal formation18.628588676452621.633930683136
19273HYHypothalamus4.179774463176733.55211585760117
19273LSXLateral septal complex2.710874840617182.12697556614876
19273MBMidbrain5.322265386581425.47948664426804
19273MYMedulla4.68604141473774.52245140075684
19273OLFOlfactory bulb4.513306498527533.54691731929779
19273PPons7.179848194122316.44587826728821
19273PALPallidum3.484237566590312.35189060866833
19273RHPRetrohippocampal region26.110651969909722.533983707428
19273sAMYStriatum-like amygdalar nuclei4.096168160438543.39296042919159
19273STRStriatum4.713634133338933.63175404071808
19273STRdStriatum dorsal region5.171153664588934.06653863191605
19273STRvStriatum ventral region3.240164130926132.13886341452599
19273THThalamus1.554631292819981.19524809718132
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10076GO:0004725IEAFunctionprotein tyrosine phosphatase activity
10076GO:0004872IEAFunctionreceptor activity
10076GO:0005001TASFunctiontransmembrane receptor protein tyrosine phosphatase activity
10076GO:0005887TASComponentintegral to plasma membrane
10076GO:0006470IEAProcessprotein amino acid dephosphorylation
10076GO:0007155TASProcesscell adhesion
10076GO:0007185TASProcesstransmembrane receptor protein tyrosine phosphatase signaling pathway
10076GO:0016020IEAComponentmembrane
10076GO:0016021IEAComponentintegral to membrane
10076GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10076IPR003962FnIII_subdFibronectin, type III subdomain
10076IPR003961FN_IIIFibronectin, type III
10076IPR000998MAMMAM
10076IPR000387TYR_phosphataseTyrosine specific protein phosphatase and dual specificity protein phosphatase
10076IPR000242Tyr_PPTyrosine specific protein phosphatase

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