Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10140
Official Symbol:TOB1
Other Aliases:APRO6|MGC104792|MGC34446|PIG49|TOB|TROB|TROB1
See related:HGNC:11979|MIM:605523|HPRD:09273
Chromosome:17
Location:17q21
Gene Description:transducer of ERBB2, 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0090
ORGANISM:human
Entrez Gene ID:10140
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.54 :: -1.43 :: -0.42 :: 0.53 :: -1.10 :: 2.10 :: 0.31 :: -0.77 :: -1.15 :: -0.72
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22057CBCerebellum100.0100.0
22057CTXCerebral cortex100.0100.0
22057HIPHippocampal region100.0100.0
22057HPFHippocampal formation100.0100.0
22057HYHypothalamus100.0100.0
22057LSXLateral septal complex100.0100.0
22057MBMidbrain100.0100.0
22057MYMedulla100.0100.0
22057OLFOlfactory bulb100.0100.0
22057PPons99.9410018920898100.0
22057PALPallidum100.0100.0
22057RHPRetrohippocampal region100.0100.0
22057sAMYStriatum-like amygdalar nuclei100.0100.0
22057STRStriatum100.0100.0
22057STRdStriatum dorsal region100.0100.0
22057STRvStriatum ventral region100.0100.0
22057THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10140GO:0005070TASFunctionSH3/SH2 adaptor activity
10140GO:0005515TASFunctionprotein binding
10140GO:0008285TASProcessnegative regulation of cell proliferation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_005740.1--SMAD8HPRD09273
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10140TOB1_HUMANP50616IPR002087Anti_prolifrtnAnti-proliferative protein

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