Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1020
Official Symbol:CDK5
Other Aliases:PSSALRE
See related:HGNC:1774|MIM:123831|HPRD:00449
Chromosome:7
Location:7q36
Gene Description:cyclin-dependent kinase 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0170
ORGANISM:human
Entrez Gene ID:1020
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12568
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVID0008
ORGANISM:human
Entrez Gene ID:1020
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:123831
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12568CBCerebellum44.602016448974650.0
12568CTXCerebral cortex50.050.0
12568HIPHippocampal region50.050.0
12568HPFHippocampal formation50.050.0
12568HYHypothalamus50.050.0
12568LSXLateral septal complex50.050.0
12568MBMidbrain50.050.0
12568MYMedulla50.050.0
12568OLFOlfactory bulb50.050.0
12568PPons50.050.0
12568PALPallidum50.050.0
12568RHPRetrohippocampal region50.050.0
12568sAMYStriatum-like amygdalar nuclei50.050.0
12568STRStriatum50.050.0
12568STRdStriatum dorsal region50.050.0
12568STRvStriatum ventral region50.050.0
12568THThalamus50.050.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1020GO:0000166IEAFunctionnucleotide binding
1020GO:0004693TASFunctioncyclin-dependent protein kinase activity
1020GO:0005176ISSFunctionErbB-2 class receptor binding
1020GO:0005515IPIFunctionprotein binding
1020GO:0005515ISSFunctionprotein binding
1020GO:0005524IEAFunctionATP binding
1020GO:0005634ISSComponentnucleus
1020GO:0005737ISSComponentcytoplasm
1020GO:0006468IEAProcessprotein amino acid phosphorylation
1020GO:0007049IEAProcesscell cycle
1020GO:0007519ISSProcessstriated muscle development
1020GO:0008283TASProcesscell proliferation
1020GO:0009790ISSProcessembryonic development
1020GO:0016020ISSComponentmembrane
1020GO:0016740IEAFunctiontransferase activity
1020GO:0030182ISSProcessneuron differentiation
1020GO:0030424ISSComponentaxon
1020GO:0030425ISSComponentdendrite
1020GO:0030426ISSComponentgrowth cone
1020GO:0030549ISSFunctionacetylcholine receptor activator activity
1020GO:0031175ISSProcessneurite development
1020GO:0031594ISSComponentneuromuscular junction
1020GO:0043025ISSComponentcell soma
1020GO:0043125ISSFunctionErbB-3 class receptor binding
1020GO:0043525ISSProcesspositive regulation of neuron apoptosis
1020GO:0048675ISSProcessaxon extension
1020GO:0050321ISSFunctiontau-protein kinase activity
1020GO:0051301IEAProcesscell division
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaHPRD00286
-6812NP_003156.1syntaxin binding protein 1 isoform aHPRD04235
-8941NP_003927.1cyclin-dependent kinase 5, regulatory subunit 2HPRD04790
-6804NP_004594.1syntaxin 1A (brain)HPRD01721
-2580NP_005246.1cyclin G associated kinaseHPRD03631
-10763NP_006608.1nestinHPRD09020
-79187NP_077309.1fibronectin type III and SPRY domain containing 1HPRD17021
-81928NP_112492.1Cdk5 and Abl enzyme substrate 2HPRD12994
NP_004926.1--SETHPRD00449
NP_004926.1--ik3-2HPRD00449
NP_004926.15111-Proliferating cell nuclear antigenHPRD00449
NP_004926.12580-Cyclin G associated kinaseHPRD00449
NP_004926.16804-Syntaxin 1AHPRD00449
NP_004926.18941-Cyclin dependent kinase 5, regulatory subunit 2HPRD00449
NP_004926.11499-Beta cateninHPRD00449
NP_004926.110763-NestinHPRD00449
NP_004926.16812-Syntaxin binding protein 1HPRD00449
NP_004926.18851NP_003876.1cyclin-dependent kinase 5, regulatory subunit 1BIND130687
NP_004926.18851NP_003876.1cyclin-dependent kinase 5, regulatory subunit 1BIND196587
NP_004926.18851NP_003876.1cyclin-dependent kinase 5, regulatory subunit 1HPRD04586
NP_004926.18851NP_003876.1cyclin-dependent kinase 5, regulatory subunit 1HPRD00449
NP_004926.11020NP_004926.1cyclin-dependent kinase 5HPRD00449
NP_004926.151654NP_057492.2CDK5 regulatory subunit associated protein 1 isoform aHPRD12189
NP_004926.191768NP_612384.1Cdk5 and Abl enzyme substrate 1HPRD16461
NP_004926.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1020CDK5_HUMANQ00535IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1020CDK5_HUMANQ00535IPR000719Prot_kinaseProtein kinase
1020CDK5_HUMANQ00535IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
1020CDK5_HUMANQ00535IPR001245Tyr_pkinaseTyrosine protein kinase
1020CDK5_HUMANQ00535IPR013695WAKWall-associated kinase

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