Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1026
Official Symbol:CDKN1A
Other Aliases:CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1
See related:HGNC:1784|MIM:116899|HPRD:00298
Chromosome:6
Location:6p21.2
Gene Description:cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0248
ORGANISM:human
Entrez Gene ID:1026
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12575
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12575CBCerebellum50.418978095054635.3683389425278
12575CTXCerebral cortex44.978014945983928.8690962791443
12575HIPHippocampal region15.51779174804699.29934477806091
12575HPFHippocampal formation18.070293903350810.5146678686142
12575HYHypothalamus11.87352681159978.53504252433777
12575LSXLateral septal complex17.49554449319849.64188605546951
12575MBMidbrain20.163658499717710.8066235780716
12575MYMedulla28.689718723297116.7596565485001
12575OLFOlfactory bulb75.204826354980554.4540119171143
12575PPons25.983829975128216.6178214550018
12575PALPallidum7.911323070526126.31462097167969
12575RHPRetrohippocampal region22.220873355865512.1879394054413
12575sAMYStriatum-like amygdalar nuclei10.51025867462167.53223180770874
12575STRStriatum8.354466438293465.16836851835251
12575STRdStriatum dorsal region6.593017339706424.32693317532539
12575STRvStriatum ventral region9.333257198333745.13778233528137
12575THThalamus9.136282682418824.76426485180855
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1026GO:0000079TASProcessregulation of cyclin dependent protein kinase activity
1026GO:0004672NRFunctionprotein kinase activity
1026GO:0004861IEAFunctioncyclin-dependent protein kinase inhibitor activity
1026GO:0004861TASFunctioncyclin-dependent protein kinase inhibitor activity
1026GO:0005515IPIFunctionprotein binding
1026GO:0005634IEAComponentnucleus
1026GO:0005634TASComponentnucleus
1026GO:0007049IEAProcesscell cycle
1026GO:0007050IEAProcesscell cycle arrest
1026GO:0007050TASProcesscell cycle arrest
1026GO:0008270IEAFunctionzinc ion binding
1026GO:0008285TASProcessnegative regulation of cell proliferation
1026GO:0008629TASProcessinduction of apoptosis by intracellular signals
1026GO:0016301IEAFunctionkinase activity
1026GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1647NP_001915.1growth arrest and DNA-damage-inducible, alphaHPRD00528
-1027NP_004055.1cyclin-dependent kinase inhibitor 1BHPRD02867
-10912NP_006696.1growth arrest and DNA-damage-inducible, gammaHPRD05383
-4616NP_056490.1growth arrest and DNA-damage-inducible, betaHPRD05382
-6774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
AF497972.1---BIND197168
NC_000006.9---BIND208276
NC_000006.9---BIND217363
NC_000006.9---BIND215873
NC_000006.9---BIND215875
NC_000006.94286--BIND214953
NC_000006.97161CAA72219.1P73BIND295556
NC_000006.95925NP_000312.1retinoblastoma 1BIND214952
NC_000006.97157NP_000537.2tumor protein p53BIND214344
NC_000006.97157NP_000537.2tumor protein p53BIND217364
NC_000006.97157NP_000537.2tumor protein p53BIND315516
NC_000006.97157NP_000537.2tumor protein p53BIND315951
NC_000006.94609NP_002458.1v-myc myelocytomatosis viral oncogene homologBIND312453
NC_000006.96597NP_003063.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4BIND218800
NC_000006.97709NP_003434.1zinc finger and BTB domain containing 17BIND312452
NC_000006.99412NP_004255.2SRB7 suppressor of RNA polymerase B homologBIND315518
NC_000006.91655NP_004387.1DEAD (Asp-Glu-Ala-Asp) box polypeptide 5BIND214327
NC_000006.95469NP_004765.2peroxisome proliferator-activated receptor binding proteinBIND315517
NC_000006.93065NP_004955.2histone deacetylase 1BIND217362
NC_000006.97161NP_005418.1tumor protein p73BIND295553
NC_000006.96667NP_612482.2Sp1 transcription factorBIND217365
NP_000380.1---BIND217626
NP_000380.1---BIND182207
NP_000380.1---BIND197054
NP_000380.1---BIND197223
NP_000380.1---BIND301677
NP_000380.1-BAC54273.1poly proteinBIND180495
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND300914
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND296554
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND258439
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND54929
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND295972
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND196345
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND197055
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND197222
NP_000380.15111NP_002583.1proliferating cell nuclear antigenBIND300977
NP_000380.18900NP_003905.1cyclin A1BIND149089
NP_000380.11387NP_004371.1CREB binding proteinBIND146170
NP_000380.1155807NP_057852.2Vpr--
NP_000380.1155807NP_057852.2Vpr--
NP_510867.11647-GADD45HPRD00298
NP_510867.14616-GADD45 betaHPRD00298
NP_510867.15111-Proliferating cell nuclear antigenHPRD00298
NP_510867.11027-Cyclin dependent kinase inhibitor 1BHPRD00298
NP_510867.110912-GADD45 gammaHPRD00298
NP_510867.16774-STAT3HPRD00298
NP_510867.15684-Proteasome subunit, alpha type 3HPRD00298
NP_510867.11460NP_001311.3casein kinase 2, beta polypeptideHPRD00278
NP_510867.11460NP_001311.3casein kinase 2, beta polypeptideHPRD00298
NP_510867.11457NP_001886.1casein kinase II alpha 1 subunit isoform aHPRD00277
NP_510867.15292NP_002639.1pim-1 oncogeneHPRD01292
NP_510867.15292NP_002639.1pim-1 oncogeneHPRD00298
NP_510867.16418NP_003002.1SET translocation (myeloid leukemia-associated)HPRD00298
NP_510867.16418NP_003002.1SET translocation (myeloid leukemia-associated)HPRD09023
NP_510867.17083NP_003249.1thymidine kinase 1, solubleHPRD00298
NP_510867.17083NP_003249.1thymidine kinase 1, solubleHPRD01771
NP_510867.18317NP_003494.1CDC7 cell division cycle 7HPRD10345
NP_510867.15425NP_006221.1polymerase (DNA directed), delta 2, regulatory subunitHPRD15982
NP_510867.15425NP_006221.1polymerase (DNA directed), delta 2, regulatory subunitBIND144551
NP_510867.17251NP_006283.1tumor susceptibility gene 101HPRD00298
NP_510867.17251NP_006283.1tumor susceptibility gene 101HPRD03229
NP_510867.125792NP_036259.2Cip1-interacting zinc finger proteinHPRD13061
NP_510867.156647NP_057651.1BRCA2 and CDKN1A-interacting protein isoform BCCIPalphaHPRD16542
NP_510867.1255488NP_877434.2IBR domain containing 2HPRD17126
NT_007592.149063--BIND183822
NT_007592.142309NP_001446.1forkhead box O3ABIND130615
NT_007592.142308NP_002006.2forkhead box O1ABIND130628
NT_007592.144609NP_002458.1v-myc myelocytomatosis viral oncogene homologBIND130634
NT_007592.144089NP_005350.1MAD, mothers against decapentaplegic homolog 4BIND130616
NT_007592.144303NP_005929.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)BIND130627
P389365111NP_002583.1proliferating cell nuclear antigenBIND295558
U24170.14193--BIND183826
U24170.17157NP_000537.2tumor protein p53BIND215046
U24170.14582NP_002447.3mucin 1, transmembraneBIND215045
U24170.11387NP_004371.1CREB binding proteinBIND215048
U24170.13065NP_004955.2histone deacetylase 1BIND215049
U24170.1121504NP_778224.1histone H4BIND215050
U24170.1121504NP_778224.1histone H4BIND258521
Z85996.13091--BIND218697
Z85996.19063--BIND218695
Z85996.14609NP_002458.1v-myc myelocytomatosis viral oncogene homologBIND218694
Z85996.16667NP_612482.2Sp1 transcription factorBIND218696
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1026CDN1A_HUMANP38936IPR003175CDICyclin-dependent kinase inhibitor

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