Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10262
Official Symbol:SF3B4
Other Aliases:MGC10828|SAP49|SF3b49
See related:HGNC:10771|MIM:605593|HPRD:12028
Chromosome:1
Location:1q12-q21
Gene Description:splicing factor 3b, subunit 4, 49kDa
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0875
ORGANISM:human
Entrez Gene ID:10262
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
107701CBCerebellum54.110198974609483.4131164550781
107701CTXCerebral cortex89.94933319091876.0179748535156
107701HIPHippocampal region72.1590118408203100.0
107701HPFHippocampal formation77.9336013793945100.0
107701HYHypothalamus31.111803054809626.3418273925781
107701LSXLateral septal complex33.277050018310527.8925037384033
107701MBMidbrain59.469921112060558.7524490356445
107701MYMedulla70.877052307128983.9240570068359
107701OLFOlfactory bulb69.591850280761763.840274810791
107701PPons62.864334106445372.0415725708008
107701PALPallidum38.76190567016635.8821830749512
107701RHPRetrohippocampal region88.985961914062583.571907043457
107701sAMYStriatum-like amygdalar nuclei46.610420227050837.0475959777832
107701STRStriatum37.035461425781228.8730297088623
107701STRdStriatum dorsal region35.125087738037127.9835319519043
107701STRvStriatum ventral region41.74113845825229.2203006744385
107701THThalamus42.725326538085937.9804763793945
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10262GO:0000166IEAFunctionnucleotide binding
10262GO:0000398ICProcessnuclear mRNA splicing, via spliceosome
10262GO:0003676IEAFunctionnucleic acid binding
10262GO:0005515IPIFunctionprotein binding
10262GO:0005681IDAComponentspliceosome complex
10262GO:0008380TASProcessRNA splicing
10262GO:0031202TASFunctionRNA splicing factor activity, transesterification mechanism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_005841.110992AAA97461.1Human spliceosome associated protein (SAP 145) mRNA, and translated productsBIND180493
NP_005841.110915NP_006697.2transcription elongation regulator 1 isoform 1HPRD12028
NP_005841.110915NP_006697.2transcription elongation regulator 1 isoform 1HPRD10393
NP_005841.110992NP_006833.2splicing factor 3B subunit 2HPRD12028
NP_005841.110992NP_006833.2splicing factor 3B subunit 2HPRD10410
NP_005841.151639NP_057131.1splicing factor 3B, 14 kDa subunitHPRD12028
NP_005841.184844NP_116147.1PHD-finger 5AHPRD12028
NP_005841.184844NP_116147.1PHD-finger 5AHPRD15126
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10262SF3B4_HUMANQ15427IPR006030Mollsc_rhodpsn_CMolluscan rhodopsin C-terminal tail
10262SF3B4_HUMANQ15427IPR003882Pistil_extensinPistil-specific extensin-like protein
10262SF3B4_HUMANQ15427IPR000694PRO_richProline-rich region
10262SF3B4_HUMANQ15427IPR000504RNP1_RNA_bdRNA-binding region RNP-1 (RNA recognition motif)

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