Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10320
Official Symbol:ZNFN1A1
Other Aliases:Hs.54452|IK1|IKAROS|LYF1|PRO0758|hIk-1
See related:HGNC:13176|MIM:603023|HPRD:04318
Chromosome:7
Location:7p13-p11.1
Gene Description:zinc finger protein, subfamily 1A, 1 (Ikaros)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0243
ORGANISM:human
Entrez Gene ID:10320
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.74
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22778CBCerebellum3.447972148656854.08115983009338
22778CTXCerebral cortex2.904197216033942.28744101524353
22778HIPHippocampal region6.440451025962834.21184879541397
22778HPFHippocampal formation5.79726970195773.95740473270416
22778HYHypothalamus1.776214599609381.07176253199577
22778LSXLateral septal complex0.9272484183311460.596720010042191
22778MBMidbrain1.751964241266251.46969386935234
22778MYMedulla5.47379527986056.14143597334623
22778OLFOlfactory bulb7.763507485389715.85640031099319
22778PPons5.376711606979373.9672247171402
22778PALPallidum1.674053609371191.09987124800682
22778RHPRetrohippocampal region4.39569032192233.35294735431671
22778sAMYStriatum-like amygdalar nuclei2.442145824432371.6776824593544
22778STRStriatum1.930912256240841.16781386733055
22778STRdStriatum dorsal region1.784867346286771.08603748679161
22778STRvStriatum ventral region2.897680550813671.57300400733948
22778THThalamus2.447153210639951.48828119039536
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10320GO:0003677TASFunctionDNA binding
10320GO:0005634IEAComponentnucleus
10320GO:0006350IEAProcesstranscription
10320GO:0006355IEAProcessregulation of transcription, DNA-dependent
10320GO:0007498TASProcessmesoderm development
10320GO:0008270IEAFunctionzinc ion binding
10320GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-22807NP_057344.1zinc finger protein, subfamily 1A, 2 (Helios)HPRD05872
-64375NP_071910.1zinc finger protein, subfamily 1A, 4 (Eos)HPRD05874
NP_006051.1--Mi-2HPRD04318
NP_006051.1--Sin3HPRD04318
NP_006051.1--TFIIBHPRD04318
NP_006051.122807-Zinc finger protein, subfamily 1A, member 2HPRD04318
NP_006051.164375-Zinc finger protein, subfamily 1A, member 4HPRD04318
NP_006051.123309AAU01916.1Long form of Human Sin3B mRNA, complete cdsHPRD09691
NP_006051.122806NP_036613.1zinc finger protein, subfamily 1A, 3 (Aiolos)HPRD05869
NP_006051.122806NP_036613.1zinc finger protein, subfamily 1A, 3 (Aiolos)HPRD04318
NP_006051.125942NP_056292.1transcriptional co-repressor Sin3AHPRD09690
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10320IKAR_HUMANQ13422IPR007087Znf_C2H2Zinc finger, C2H2-type
10320IKAR_HUMANQ13422IPR007086Znf_C2H2_subZinc finger, C2H2-subtype

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