Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10379
Official Symbol:ISGF3G
Other Aliases:IRF-9|IRF9|ISGF3|p48
See related:HGNC:6131|MIM:147574|HPRD:00960
Chromosome:14
Location:14q11.2
Gene Description:interferon-stimulated transcription factor 3, gamma 48kDa
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0137
ORGANISM:human
Entrez Gene ID:10379
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.01 :: 0.78 :: 1.79 :: 1.39 :: -3.15 :: -1.93 :: -2.08
KARG Evidence 2
KARG ID:QTL0205
ORGANISM:human
Entrez Gene ID:10379
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
268749CBCerebellum32.674423217773433.590518951416
268749CTXCerebral cortex24.006343841552715.4261388778687
268749HIPHippocampal region29.283590316772533.6272735595703
268749HPFHippocampal formation28.045995712280326.208179473877
268749HYHypothalamus16.204744338989311.2315120697021
268749LSXLateral septal complex8.203974723815925.00459432601929
268749MBMidbrain19.324934005737314.8915071487427
268749MYMedulla30.725151062011727.9365768432617
268749OLFOlfactory bulb41.092819213867229.3109092712402
268749PPons27.646009445190424.057918548584
268749PALPallidum10.48564052581797.68379831314087
268749RHPRetrohippocampal region25.690959930419917.534158706665
268749sAMYStriatum-like amygdalar nuclei17.031240463256810.9556188583374
268749STRStriatum9.208650588989266.15386629104614
268749STRdStriatum dorsal region6.750626564025884.7082576751709
268749STRvStriatum ventral region12.56036186218267.75003623962402
268749THThalamus28.121973037719720.7193279266357
KARG Evidence 3
KARG ID:QTL0205
Trait:cocaine seizure
Peak:21.5
Peak Marker:NA
Parents:(C57BL/6J x DBA/2J)F2 intercross
Evidence ID:10734168
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10379GO:0003700TASFunctiontranscription factor activity
10379GO:0005515IEAFunctionprotein binding
10379GO:0005634TASComponentnucleus
10379GO:0005737TASComponentcytoplasm
10379GO:0006350IEAProcesstranscription
10379GO:0006355IEAProcessregulation of transcription, DNA-dependent
10379GO:0006366TASProcesstranscription from RNA polymerase II promoter
10379GO:0006955IEAProcessimmune response
10379GO:0007166TASProcesscell surface receptor linked signal transduction
10379GO:0008270IEAFunctionzinc ion binding
10379GO:0009615IEAProcessresponse to virus
10379GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10379IRTF_HUMANQ00978IPR001346IRFInterferon regulatory factor

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