Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10486
Official Symbol:CAP2
Other Aliases:-
See related:HGNC:20039|HPRD:10808
Chromosome:6
Location:6p22.3
Gene Description:CAP, adenylate cyclase-associated protein, 2 (yeast)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0393
ORGANISM:human
Entrez Gene ID:10486
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-1.6 :: 1.3 :: 1.5 :: 1.1 :: 1.3 :: -1.4
KARG Evidence 2
KARG ID:EVIM0461
ORGANISM:human
Entrez Gene ID:10486
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.7 :: -1.4 :: -1.2 :: -1.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
67252CBCerebellum19.204674720764268.3462314605713
67252CTXCerebral cortex100.0100.0
67252HIPHippocampal region95.2254676818848100.0
67252HPFHippocampal formation89.362663269043100.0
67252HYHypothalamus5.846921205520634.77903735637665
67252LSXLateral septal complex52.76849746704146.4217987060547
67252MBMidbrain21.95209407806421.1389379501343
67252MYMedulla17.484527111053519.8781752586365
67252OLFOlfactory bulb70.552551269531278.5410614013672
67252PPons15.880052566528316.5173802375793
67252PALPallidum19.527406692504917.6111164093018
67252RHPRetrohippocampal region82.384037017822389.4906272888184
67252sAMYStriatum-like amygdalar nuclei38.333495140075732.3610219955444
67252STRStriatum85.431343078613373.8305606842041
67252STRdStriatum dorsal region90.028202056884879.9369506835938
67252STRvStriatum ventral region93.328147888183685.2634048461914
67252THThalamus39.466108322143638.7823781967163
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10486GO:0007163TASProcessestablishment and/or maintenance of cell polarity
10486GO:0007165TASProcesssignal transduction
10486GO:0007190TASProcessadenylate cyclase activation
10486GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_006357.110487NP_006358.1adenylyl cyclase-associated proteinHPRD10808
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10486CAP2_HUMANP40123IPR001837CAPCAP protein
10486CAP2_HUMANP40123IPR001670Fe_ADHIron-containing alcohol dehydrogenase
10486CAP2_HUMANP40123IPR000694PRO_richProline-rich region

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