Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1051
Official Symbol:CEBPB
Other Aliases:C/EBP-beta|CRP2|IL6DBP|LAP|MGC32080|NF-IL6|TCF5
See related:HGNC:1834|MIM:189965|HPRD:01801
Chromosome:20
Location:20q13.1
Gene Description:CCAAT/enhancer binding protein (C/EBP), beta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0575
ORGANISM:human
Entrez Gene ID:1051
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24253
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12606CBCerebellum100.0100.0
12606CTXCerebral cortex100.0100.0
12606HIPHippocampal region100.0100.0
12606HPFHippocampal formation100.0100.0
12606HYHypothalamus100.0100.0
12606LSXLateral septal complex100.084.9240303039551
12606MBMidbrain100.099.5085716247559
12606MYMedulla100.0100.0
12606OLFOlfactory bulb100.0100.0
12606PPons100.0100.0
12606PALPallidum100.0100.0
12606RHPRetrohippocampal region100.0100.0
12606sAMYStriatum-like amygdalar nuclei100.0100.0
12606STRStriatum100.096.329532623291
12606STRdStriatum dorsal region100.094.5238609313965
12606STRvStriatum ventral region100.0100.0
12606THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1051GO:0003700NASFunctiontranscription factor activity
1051GO:0005634TASComponentnucleus
1051GO:0006350IEAProcesstranscription
1051GO:0006355IEAProcessregulation of transcription, DNA-dependent
1051GO:0006366TASProcesstranscription from RNA polymerase II promoter
1051GO:0006953TASProcessacute-phase response
1051GO:0006954TASProcessinflammatory response
1051GO:0043565IEAFunctionsequence-specific DNA binding
1051GO:0046983IEAFunctionprotein dimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9221AAH01883.1Nucleolar and coiled-body phosphoprotein 1HPRD03864
-2908NP_000167.1nuclear receptor subfamily 3, group C, member 1 isoform alphaHPRD00679
-2033NP_001420.1E1A binding protein p300HPRD04078
-1054NP_001797.1CCAAT/enhancer binding protein gammaHPRD00738
-1386NP_001871.2activating transcription factor 2HPRD00443
-3190NP_002131.2heterogeneous nuclear ribonucleoprotein K isoform aHPRD02834
-6597NP_003063.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4HPRD04459
-6598NP_003064.2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 isoform aHPRD03364
-6688NP_003111.1spleen focus forming virus (SFFV) proviral integration oncogene spi1HPRD01305
-6722NP_003122.1serum response factor (c-fos serum response element-binding transcription factor)HPRD02788
-6776NP_003143.2signal transducer and activator of transcription 5AHPRD03301
-6778NP_003144.3signal transducer and activator of transcription 6HPRD03302
-4790NP_003989.1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)HPRD01238
-1649NP_004074.2DNA-damage-inducible transcript 3HPRD00529
-1052NP_005186.2CCAAT/enhancer binding protein deltaHPRD00297
-1956NP_005219.1epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)HPRD00579
-2002NP_005220.1ELK1 proteinHPRD02407
-10155NP_005753.1tripartite motif-containing 28 proteinHPRD03445
-4088NP_005893.1MAD, mothers against decapentaplegic homolog 3HPRD04380
-5970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD01241
-1385NP_604391.1cAMP responsive element binding protein 1 isoform BHPRD00442
-6667NP_612482.2Sp1 transcription factorHPRD01796
-3159NP_665906.1high mobility group AT-hook 1 isoform aHPRD02829
NP_005185.2--RNA polymerase IIHPRD01801
NP_005185.24790-NFKB1HPRD01801
NP_005185.21649-CHOPHPRD01801
NP_005185.22002-ELK 1HPRD01801
NP_005185.21052-CCAAT/enhancer binding deltaHPRD01801
NP_005185.26688-SPI1HPRD01801
NP_005185.29221-Nucleolar phosphoprotein p130HPRD01801
NP_005185.21386-Activating transcription factor 2HPRD01801
NP_005185.22033-E1A binding protein p300HPRD01801
NP_005185.23190-Heterogeneous nuclear ribonucleoprotein KHPRD01801
NP_005185.25970-NFKB3HPRD01801
NP_005185.26778-STAT6HPRD01801
NP_005185.210155-Transcriptional intermediary factor 1 betaHPRD01801
NP_005185.22908-Glucocorticoid receptorHPRD01801
NP_005185.26597-SMARCA4HPRD01801
NP_005185.26598-SMARCB1HPRD01801
NP_005185.26776-STAT5AHPRD01801
NP_005185.26722-Serum response factorHPRD01801
NP_005185.21956-EGF receptorHPRD01801
NP_005185.21054-CCAAT/Enhancer binding protein gammaHPRD01801
NP_005185.24088-SMAD3HPRD01801
NP_005185.23159-High mobility group AT hook 1HPRD01801
NP_005185.21385-Active transcription factor CREBHPRD01801
NP_005185.26667-Transcription factor Sp1HPRD01801
NP_005185.25553M34462.1Human eosinophil major basic protein gene, and translated productsBIND182588
NP_005185.22099NP_000116.1estrogen receptor 1HPRD01801
NP_005185.22099NP_000116.1estrogen receptor 1HPRD00589
NP_005185.25925NP_000312.1retinoblastoma 1HPRD01801
NP_005185.25925NP_000312.1retinoblastoma 1HPRD01574
NP_005185.21958NP_001955.1early growth response 1HPRD01801
NP_005185.21958NP_001955.1early growth response 1HPRD00549
NP_005185.21958NP_001955.1early growth response 1BIND181840
NP_005185.22308NP_002006.2forkhead box O1AHPRD01801
NP_005185.22308NP_002006.2forkhead box O1AHPRD00645
NP_005185.24609NP_002458.1v-myc myelocytomatosis viral oncogene homologHPRD01801
NP_005185.24609NP_002458.1v-myc myelocytomatosis viral oncogene homologHPRD01818
NP_005185.26599NP_003065.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin c1HPRD03435
NP_005185.26599NP_003065.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin c1HPRD01801
NP_005185.26880NP_003178.1TAF9 RNA polymerase II isoform aHPRD15983
NP_005185.21649NP_004074.2DNA-damage-inducible transcript 3BIND257628
NP_005185.29439NP_004821.1cofactor required for Sp1 transcriptional activation, subunit 3, 130kDaHPRD05436
NP_005185.29439NP_004821.1cofactor required for Sp1 transcriptional activation, subunit 3, 130kDaHPRD01801
NP_005185.24089NP_005350.1MAD, mothers against decapentaplegic homolog 4BIND258683
NP_005185.24089NP_005350.1MAD, mothers against decapentaplegic homolog 4HPRD01801
NP_005185.24089NP_005350.1MAD, mothers against decapentaplegic homolog 4HPRD02995
NP_005185.24602NP_005366.1v-myb myeloblastosis viral oncogene homologHPRD01801
NP_005185.24602NP_005366.1v-myb myeloblastosis viral oncogene homologHPRD01810
NP_005185.23297NP_005517.1heat shock transcription factor 1HPRD01801
NP_005185.23297NP_005517.1heat shock transcription factor 1HPRD00778
NP_005185.2155807NP_057852.2Vpr--
NP_005185.2155807NP_057852.2Vpr--
NP_005185.2155871NP_057853.1Tat--
NP_005185.2155871NP_057853.1Tat--
NP_005185.2155871NP_057853.1Tat--
NP_005185.2155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1051CEBPB_HUMANP17676IPR011616bZIP_1bZIP transcription factor, bZIP_1
1051CEBPB_HUMANP17676IPR011700bZIP_2Basic leucine zipper
1051CEBPB_HUMANP17676IPR000694PRO_richProline-rich region
1051CEBPB_HUMANP17676IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor

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