Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10522
Official Symbol:DEAF1
Other Aliases:NUDR|SPN|ZMYND5
See related:HGNC:14677|MIM:602635|HPRD:04027
Chromosome:11
Location:11p15.5
Gene Description:deformed epidermal autoregulatory factor 1 (Drosophila)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0056
ORGANISM:human
Entrez Gene ID:10522
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.66 :: -0.47 :: 0.13 :: 0.07 :: -0.57 :: -0.30 :: -0.67 :: -0.45 :: 0.14 :: -0.55
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
54006CBCerebellum100.0100.0
54006CTXCerebral cortex100.0100.0
54006HIPHippocampal region100.0100.0
54006HPFHippocampal formation100.0100.0
54006HYHypothalamus93.831855773925881.7792129516602
54006LSXLateral septal complex76.485015869140661.223690032959
54006MBMidbrain83.749282836914178.7036514282227
54006MYMedulla52.907608032226651.4201126098633
54006OLFOlfactory bulb100.0100.0
54006PPons72.676132202148467.8720550537109
54006PALPallidum90.949302673339886.5290603637695
54006RHPRetrohippocampal region100.0100.0
54006sAMYStriatum-like amygdalar nuclei100.0100.0
54006STRStriatum100.0100.0
54006STRdStriatum dorsal region100.0100.0
54006STRvStriatum ventral region100.0100.0
54006THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10522GO:0003677IEAFunctionDNA binding
10522GO:0005634IEAComponentnucleus
10522GO:0005634TASComponentnucleus
10522GO:0006350IEAProcesstranscription
10522GO:0006355IEAProcessregulation of transcription, DNA-dependent
10522GO:0006366TASProcesstranscription from RNA polymerase II promoter
10522GO:0007281TASProcessgerm cell development
10522GO:0008270IEAFunctionzinc ion binding
10522GO:0009653TASProcessmorphogenesis
10522GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_066288.2---BIND151392
NP_066288.210522NP_066288.2suppressinBIND151393
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10522DEAF1_HUMANO75398IPR000104Antifreeze_1Antifreeze protein, type I
10522DEAF1_HUMANO75398IPR003072NOR1_rcptOrphan nuclear receptor, NOR1 type
10522DEAF1_HUMANO75398IPR000770SANDSAND
10522DEAF1_HUMANO75398IPR002893Znf_MYNDZinc finger, MYND-type

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