Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10681
Official Symbol:GNB5
Other Aliases:FLJ37457|GB5
See related:HGNC:4401|MIM:604447|HPRD:09191
Chromosome:15
Location:15q21.2
Gene Description:guanine nucleotide binding protein (G protein), beta 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0086
ORGANISM:human
Entrez Gene ID:10681
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14697
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0142
ORGANISM:human
Entrez Gene ID:10681
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14697CBCerebellum39.522335052490232.7167444229126
14697CTXCerebral cortex53.478603363037143.0381736755371
14697HIPHippocampal region47.74905967712440.8081703186035
14697HPFHippocampal formation42.92456054687535.9325351715088
14697HYHypothalamus10.72250747680667.13100981712341
14697LSXLateral septal complex9.534502089023596.21737504005432
14697MBMidbrain11.62309980392469.16395664215088
14697MYMedulla22.987176418304419.321722984314
14697OLFOlfactory bulb68.823160171508843.1628856658936
14697PPons18.55911827087414.6960682868958
14697PALPallidum24.48133373260519.9175395965576
14697RHPRetrohippocampal region36.401389122009328.371280670166
14697sAMYStriatum-like amygdalar nuclei27.665554046630918.1985230445862
14697STRStriatum100.0100.0
14697STRdStriatum dorsal region100.0100.0
14697STRvStriatum ventral region100.098.2821311950684
14697THThalamus26.020493507385319.8539667129517
KARG Evidence 3
KARG ID:QTL0142
Trait:differences in cocaine responsiveness
Peak:41
Peak Marker:D9Nds2
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:7932176
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10681GO:0003924NASFunctionGTPase activity
10681GO:0004871IEAFunctionsignal transducer activity
10681GO:0004871NASFunctionsignal transducer activity
10681GO:0005834NASComponentheterotrimeric G-protein complex
10681GO:0007165IEAProcesssignal transduction
10681GO:0007165NASProcesssignal transduction
10681GO:0008270IEAFunctionzinc ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_057278.2--GNG1HPRD09191
NP_057278.2--GNG2HPRD09191
NP_057278.2--GNG3HPRD09191
NP_057278.2--GNG4HPRD09191
NP_057278.2--GNG5HPRD09191
NP_057278.2--GNG7HPRD09191
NP_057278.251764NP_057625.1guanine nucleotide binding protein (G protein), gamma 13HPRD12116
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10681GBB5_HUMANO14775IPR001632Gprotein_BG-protein, beta subunit
10681GBB5_HUMANO14775IPR013577LLGL2Lethal giant larvae homologue 2
10681GBB5_HUMANO14775IPR001680WD40WD-40 repeat

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