Knowledgebase for Addiction-Related Genes
KARG (Knowledgebase for Addiction Related
>> Gene Entry
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.
Basic Information Gene ID: 10891 Official Symbol: PPARGC1A Other Aliases: LEM6|PGC-1(alpha)|PGC-1v|PGC1|PGC1A|PPARGC1 See related: HGNC:9237|MIM:604517|HPRD:05155 Chromosome: 4 Location: 4p15.1 Gene Description: peroxisome proliferative activated receptor, gamma, coactivator 1, alpha Gene type: protein-coding Gene Structure: Genomic Context:
KARG Evidence 1 KARG ID: EVIC0151 ORGANISM: human Entrez Gene ID: 10891 Evidence Type: Mapping from mouse Evidence ID Type: Entrez Gene Evidence ID: 19017 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density
Gene Ontology Gene ID GO ID Evidence GO Type GO Description 10891 GO:0000166 IEA Function nucleotide binding 10891 GO:0001659 TAS Process thermoregulation 10891 GO:0001678 NAS Process cell glucose homeostasis 10891 GO:0003677 TAS Function DNA binding 10891 GO:0003723 TAS Function RNA binding 10891 GO:0005634 TAS Component nucleus 10891 GO:0005665 TAS Component DNA-directed RNA polymerase II, core complex 10891 GO:0006094 NAS Process gluconeogenesis 10891 GO:0006350 IEA Process transcription 10891 GO:0006367 TAS Process transcription initiation from RNA polymerase II promoter 10891 GO:0006397 TAS Process mRNA processing 10891 GO:0006461 TAS Process protein complex assembly 10891 GO:0007005 NAS Process mitochondrion organization and biogenesis 10891 GO:0007586 TAS Process digestion 10891 GO:0008134 TAS Function transcription factor binding 10891 GO:0008380 TAS Process RNA splicing 10891 GO:0016455 TAS Function RNA polymerase II transcription mediator activity 10891 GO:0019395 NAS Process fatty acid oxidation 10891 GO:0030374 TAS Function ligand-dependent nuclear receptor transcription coactivator activity 10891 GO:0030521 NAS Process androgen receptor signaling pathway 10891 GO:0035066 TAS Process positive regulation of histone acetylation 10891 GO:0042594 NAS Process response to starvation 10891 GO:0045333 TAS Process cellular respiration 10891 GO:0045722 TAS Process positive regulation of gluconeogenesis 10891 GO:0045893 NAS Process positive regulation of transcription, DNA-dependent 10891 GO:0046321 TAS Process positive regulation of fatty acid oxidation 10891 GO:0050681 NAS Function androgen receptor binding 10891 GO:0050821 TAS Process protein stabilization 10891 GO:0050873 TAS Process brown fat cell differentiation
Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID
Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 10891 PRGC1_HUMAN Q9UBK2 IPR000504 RNP1_RNA_bd RNA-binding region RNP-1 (RNA recognition motif)
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