Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:10924
Official Symbol:SMPDL3A
Other Aliases:ASM3A|ASML3a|FLJ20177|yR36GH4.1
See related:HGNC:17389|HPRD:10244
Chromosome:6
Location:6q22.31
Gene Description:sphingomyelin phosphodiesterase, acid-like 3A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0177
ORGANISM:human
Entrez Gene ID:10924
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0181
ORGANISM:human
Entrez Gene ID:10924
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
57319CBCerebellum10.742184638977111.8511762619019
57319CTXCerebral cortex1.163164377212520.898705065250397
57319HIPHippocampal region4.179253101348884.02609491348267
57319HPFHippocampal formation2.850955963134772.58410620689392
57319HYHypothalamus0.3007287383079530.173378482460976
57319LSXLateral septal complex0.8565871715545650.455501973628998
57319MBMidbrain0.8614751696586610.813187003135681
57319MYMedulla3.104901075363162.93163776397705
57319OLFOlfactory bulb2.60549616813661.60626244544983
57319PPons2.771295070648192.81593561172485
57319PALPallidum0.502038121223450.290686786174774
57319RHPRetrohippocampal region0.5098595023155210.470766514539719
57319sAMYStriatum-like amygdalar nuclei2.567478895187381.66510951519012
57319STRStriatum1.02167606353760.737336337566376
57319STRdStriatum dorsal region0.9695996046066280.761162936687469
57319STRvStriatum ventral region0.6944025158882140.517739117145538
57319THThalamus1.229350566864011.1484067440033
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
10924GO:0000004NDProcessbiological process unknown
10924GO:0005515IPIFunctionprotein binding
10924GO:0005576NASComponentextracellular region
10924GO:0005975IEAProcesscarbohydrate metabolism
10924GO:0016798IEAFunctionhydrolase activity, acting on glycosyl bonds
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
10924ASM3A_HUMANQ92484IPR004843M-pesteraseMetallophosphoesterase
10924ASM3A_HUMANQ92484IPR013622Metallophos_CCalcineurin-like phosphoesterase C-terminal

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