Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:11011
Official Symbol:TLK2
Other Aliases:MGC44450|PKU-ALPHA
See related:HGNC:11842|MIM:608439
Chromosome:17
Location:17q23
Gene Description:tousled-like kinase 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0863
ORGANISM:human
Entrez Gene ID:11011
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.9 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
24086CBCerebellum11.97263526916513.9428033828735
24086CTXCerebral cortex22.038940429687515.7379970550537
24086HIPHippocampal region19.822599411010718.8924312591553
24086HPFHippocampal formation16.940090179443415.0840587615967
24086HYHypothalamus3.922361373901373.51913452148438
24086LSXLateral septal complex7.698590278625495.33060359954834
24086MBMidbrain10.04260730743419.14457702636719
24086MYMedulla16.536165237426817.689115524292
24086OLFOlfactory bulb17.295219421386712.7856721878052
24086PPons8.430889129638679.44892406463623
24086PALPallidum6.490971088409426.3048152923584
24086RHPRetrohippocampal region11.99637222290049.78870010375977
24086sAMYStriatum-like amygdalar nuclei3.303612709045412.3210072517395
24086STRStriatum6.268433094024664.74195289611816
24086STRdStriatum dorsal region6.359677791595465.04867887496948
24086STRvStriatum ventral region6.997507572174074.44278478622437
24086THThalamus11.823593139648410.1370897293091
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
11011GO:0000166IEAFunctionnucleotide binding
11011GO:0001672IDAProcessregulation of chromatin assembly or disassembly
11011GO:0004674IDAFunctionprotein serine/threonine kinase activity
11011GO:0004674NASFunctionprotein serine/threonine kinase activity
11011GO:0005524IDAFunctionATP binding
11011GO:0005634IEPComponentnucleus
11011GO:0005634NASComponentnucleus
11011GO:0006468IDAProcessprotein amino acid phosphorylation
11011GO:0006974IEAProcessresponse to DNA damage stimulus
11011GO:0007049IEAProcesscell cycle
11011GO:0007242IDAProcessintracellular signaling cascade
11011GO:0016568IEAProcesschromatin modification
11011GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
AAH44925.111011AAH44925.1TLK2 proteinHPRD10527
AAH44925.125842NP_054753.1ASF1 anti-silencing function 1 homolog AHPRD10527
AAH44925.125842NP_054753.1ASF1 anti-silencing function 1 homolog AHPRD16459
AAH44925.155723NP_060624.1anti-silencing function 1BHPRD10527
AAH44925.155723NP_060624.1anti-silencing function 1BHPRD16460
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
11011IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
11011IPR000719Prot_kinaseProtein kinase
11011IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
11011IPR013695WAKWall-associated kinase

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