Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:111
Official Symbol:ADCY5
Other Aliases:-
See related:HGNC:236|MIM:600293|HPRD:08973
Chromosome:3
Location:3q13.2-q21
Gene Description:adenylate cyclase 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0049
ORGANISM:human
Entrez Gene ID:111
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:224129
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
224129CBCerebellum34.447142601013226.335768699646
224129CTXCerebral cortex46.176450729370129.7174215316772
224129HIPHippocampal region57.036710739135737.1122798919678
224129HPFHippocampal formation67.307701110839847.857666015625
224129HYHypothalamus76.888172149658251.0344676971436
224129LSXLateral septal complex100.096.9973297119141
224129MBMidbrain42.610511779785229.7486486434937
224129MYMedulla49.328174591064537.9177417755127
224129OLFOlfactory bulb92.831821441650464.194019317627
224129PPons38.190973281860429.0880632400513
224129PALPallidum59.573328018188553.9559440612793
224129RHPRetrohippocampal region84.550758361816461.7430973052979
224129sAMYStriatum-like amygdalar nuclei100.080.4067878723145
224129STRStriatum100.0100.0
224129STRdStriatum dorsal region100.0100.0
224129STRvStriatum ventral region100.0100.0
224129THThalamus52.615175247192435.3394184112549
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
111GO:0000287IEAFunctionmagnesium ion binding
111GO:0004016IEAFunctionadenylate cyclase activity
111GO:0006171IEAProcesscAMP biosynthesis
111GO:0007242IEAProcessintracellular signaling cascade
111GO:0016020IEAComponentmembrane
111GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2770NP_002060.3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1HPRD00756
-5997NP_002914.1regulator of G-protein signalling 2, 24kDaHPRD02917
-2778NP_536350.1guanine nucleotide binding protein, alpha stimulating activity polypeptide 1 isoform cHPRD00761
NP_899200.1--PKAHPRD08973
NP_899200.15578-Protein kinase C alphaHPRD08973
NP_899200.15590-Protein kinase C, zetaHPRD08973
NP_899200.12778-Guanine nucleotide binding protein G(S), alpha subunitHPRD08973
NP_899200.12770-G protein, alpha inhibiting 1HPRD08973
NP_899200.15997-RGS2HPRD08973
NP_899200.1111NP_899200.1adenylate cyclase 5HPRD08973
NP_899200.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
111ADCY5_HUMANO95622IPR001054A/G_cyclaseAdenylyl cyclase class-3/4/guanylyl cyclase
111ADCY5_HUMANO95622IPR009398Aden_cycl_likeAdenylate cyclase-like

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