Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:112
Official Symbol:ADCY6
Other Aliases:DKFZp779F075|KIAA0422
See related:HGNC:237|MIM:600294|HPRD:02621
Chromosome:12
Location:12q12-q13
Gene Description:adenylate cyclase 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0550
ORGANISM:human
Entrez Gene ID:112
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25289
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11512CBCerebellum2.98290842771532.99121356010437
11512CTXCerebral cortex10.21433162689215.94793021678925
11512HIPHippocampal region21.91701030731212.6811847686768
11512HPFHippocampal formation21.115920066833512.6520481109619
11512HYHypothalamus12.8341650962836.92770099639893
11512LSXLateral septal complex4.752902030944822.43974113464355
11512MBMidbrain3.9730601310732.59696102142334
11512MYMedulla5.716535449028023.734992146492
11512OLFOlfactory bulb16.98025846481329.08940649032593
11512PPons4.999230384826663.14856278896332
11512PALPallidum7.795961380004884.73116672039032
11512RHPRetrohippocampal region20.366837501525912.4265117645264
11512sAMYStriatum-like amygdalar nuclei35.992424011230520.2157301902771
11512STRStriatum6.735632896423343.96257281303406
11512STRdStriatum dorsal region3.645304620265962.35620307922363
11512STRvStriatum ventral region4.427696108818052.43473023176193
11512THThalamus8.363087892532354.38419258594513
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
112GO:0000287IEAFunctionmagnesium ion binding
112GO:0004016IEAFunctionadenylate cyclase activity
112GO:0006171IEAProcesscAMP biosynthesis
112GO:0007242IEAProcessintracellular signaling cascade
112GO:0016020IEAComponentmembrane
112GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1139NP_000737.1cholinergic receptor, nicotinic, alpha 7 precursorHPRD00339
-2778NP_536350.1guanine nucleotide binding protein, alpha stimulating activity polypeptide 1 isoform cHPRD00761
NP_056085.1--GalphasHPRD02621
NP_056085.12778-Guanine nucleotide binding protein G(S), alpha subunitHPRD02621
NP_056085.11139-Cholinergic receptor neuronal nicotinic alpha polypeptide 7HPRD02621
NP_056085.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
112IPR001054A/G_cyclaseAdenylyl cyclase class-3/4/guanylyl cyclase
112IPR009398Aden_cycl_likeAdenylate cyclase-like
112ADCY6_HUMANO43306IPR001054A/G_cyclaseAdenylyl cyclase class-3/4/guanylyl cyclase
112ADCY6_HUMANO43306IPR009398Aden_cycl_likeAdenylate cyclase-like

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.