Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1124
Official Symbol:CHN2
Other Aliases:ARHGAP3|BCH|MGC138360|RHOGAP3
See related:HGNC:1944|MIM:602857|HPRD:04173
Chromosome:7
Location:7p15.3
Gene Description:chimerin (chimaerin) 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0330
ORGANISM:human
Entrez Gene ID:1124
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.71
KARG Evidence 2
KARG ID:HOT0266
ORGANISM:human
Entrez Gene ID:1124
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
69993CBCerebellum100.0100.0
69993CTXCerebral cortex29.764519691467323.4389386177063
69993HIPHippocampal region9.811332941055311.1711208820343
69993HPFHippocampal formation11.239316463470511.8527765274048
69993HYHypothalamus22.483043909072919.9888803958893
69993LSXLateral septal complex79.252372741699283.5569076538086
69993MBMidbrain18.047267913818417.9219968318939
69993MYMedulla29.274339675903332.3258094787598
69993OLFOlfactory bulb37.566519737243736.2118988037109
69993PPons20.719293117523221.6763727664948
69993PALPallidum38.568506240844740.4932174682617
69993RHPRetrohippocampal region14.005192756652813.0442152023315
69993sAMYStriatum-like amygdalar nuclei37.509864807128934.0260648727417
69993STRStriatum41.439860343933140.5671405792236
69993STRdStriatum dorsal region26.300613880157524.2267413139343
69993STRvStriatum ventral region72.908761978149473.6956691741943
69993THThalamus24.444245815277123.1200442314148
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1124GO:0005070TASFunctionSH3/SH2 adaptor activity
1124GO:0005096TASFunctionGTPase activator activity
1124GO:0007242IEAProcessintracellular signaling cascade
1124GO:0008270IEAFunctionzinc ion binding
1124GO:0019992IEAFunctiondiacylglycerol binding
1124GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_004058.1--RacHPRD04173
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1124CHIO_HUMANP52757IPR002219DAG_PE_bdProtein kinase C, phorbol ester/diacylglycerol binding
1124CHIO_HUMANP52757IPR013625PTBTensin phosphotyrosine-binding domain
1124CHIO_HUMANP52757IPR000198RhoGAPRhoGAP
1124CHIO_HUMANP52757IPR000980SH2SH2 motif

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