Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:11280
Official Symbol:SCN11A
Other Aliases:NAV1.9|SCN12A
See related:HGNC:10583|MIM:604385|HPRD:05090
Chromosome:3
Location:3p24-p21
Gene Description:sodium channel, voltage-gated, type XI, alpha
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0157
ORGANISM:human
Entrez Gene ID:11280
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0158
ORGANISM:human
Entrez Gene ID:11280
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:QTL0159
ORGANISM:human
Entrez Gene ID:11280
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
24046CBCerebellum55.544227600097777.7312316894531
24046CTXCerebral cortex100.0100.0
24046HIPHippocampal region70.7008590698242100.0
24046HPFHippocampal formation82.8916549682617100.0
24046HYHypothalamus72.388725280761761.5296783447266
24046LSXLateral septal complex72.191734313964857.2009773254395
24046MBMidbrain61.104389190673858.6807136535645
24046MYMedulla66.301742553710972.9127578735352
24046OLFOlfactory bulb100.097.0961532592773
24046PPons63.926387786865268.7278137207031
24046PALPallidum75.975128173828172.785530090332
24046RHPRetrohippocampal region100.0100.0
24046sAMYStriatum-like amygdalar nuclei100.093.3073348999023
24046STRStriatum100.081.2279281616211
24046STRdStriatum dorsal region100.082.391487121582
24046STRvStriatum ventral region100.090.5874938964844
24046THThalamus94.439865112304786.298942565918
KARG Evidence 4
KARG ID:QTL0157
Trait:METH responses for body temperature
Peak:71
Peak Marker:Cck
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
KARG Evidence 5
KARG ID:QTL0158
Trait:METH responses for body temperature
Peak:71
Peak Marker:D9Byu6
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
KARG Evidence 6
KARG ID:QTL0159
Trait:ethanol withdrawal
Peak:71
Peak Marker:D9Byu6
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:9655868
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
11280GO:0001518IEAComponentvoltage-gated sodium channel complex
11280GO:0005248TASFunctionvoltage-gated sodium channel activity
11280GO:0005261IEAFunctioncation channel activity
11280GO:0005624NRComponentmembrane fraction
11280GO:0006812IEAProcesscation transport
11280GO:0006814TASProcesssodium ion transport
11280GO:0007268NRProcesssynaptic transmission
11280GO:0016020IEAComponentmembrane
11280GO:0031402IEAFunctionsodium ion binding
11280GO:0042493TASProcessresponse to drug
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
11280SC11A_HUMANQ9UI33IPR001682Ca/Na_poreCa2+/Na+ channel, pore region
11280SC11A_HUMANQ9UI33IPR002111Cat_channel_TrpLCation (not K+) channel, TM region
11280SC11A_HUMANQ9UI33IPR002077Ca_channel_alphaCa2+ channel, alpha subunit
11280SC11A_HUMANQ9UI33IPR005821Ion_transIon transport
11280SC11A_HUMANQ9UI33IPR013621Ion_trans_NIon transport N-terminal
11280SC11A_HUMANQ9UI33IPR003091K_channelVoltage-dependent potassium channel
11280SC11A_HUMANQ9UI33IPR005820M+channel_nlgCation channel, non-ligand gated
11280SC11A_HUMANQ9UI33IPR001696Na_channelNa+ channel
11280SC11A_HUMANQ9UI33IPR010526Na_trans_assocSodium ion transport-associated

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