Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1134
Official Symbol:CHRNA1
Other Aliases:ACHRA|ACHRD|CHRNA|CMS2A|FCCMS|SCCMS
See related:HGNC:1955|MIM:100690|HPRD:00007
Chromosome:2
Location:2q24-q32
Gene Description:cholinergic receptor, nicotinic, alpha 1 (muscle)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0344
ORGANISM:human
Entrez Gene ID:1134
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:11435
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11435CBCerebellum66.40270233154390.6315498352051
11435CTXCerebral cortex100.090.6614646911621
11435HIPHippocampal region54.203964233398462.3085880279541
11435HPFHippocampal formation76.870290756225673.6064167022705
11435HYHypothalamus83.318851470947366.8767204284668
11435LSXLateral septal complex90.371566772460981.5898399353027
11435MBMidbrain60.878394126892141.8243055343628
11435MYMedulla67.843126296997154.6088409423828
11435OLFOlfactory bulb93.629375457763794.7125587463379
11435PPons63.02544498443651.4630184173584
11435PALPallidum80.611108779907275.5172061920166
11435RHPRetrohippocampal region85.453918457031281.9848461151123
11435sAMYStriatum-like amygdalar nuclei90.978019714355578.8602313995361
11435STRStriatum84.611858367919977.5628604888916
11435STRdStriatum dorsal region78.970985412597772.7869911193848
11435STRvStriatum ventral region97.287368774414187.9161796569824
11435THThalamus67.271034240722750.0704307556152
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1134GO:0004889TASFunctionnicotinic acetylcholine-activated cation-selective channel activity
1134GO:0005216TASFunctionion channel activity
1134GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
1134GO:0005892TASComponentnicotinic acetylcholine-gated receptor-channel complex
1134GO:0006811IEAProcession transport
1134GO:0006936TASProcessmuscle contraction
1134GO:0007165TASProcesssignal transduction
1134GO:0015464TASFunctionacetylcholine receptor activity
1134GO:0016021IEAComponentintegral to membrane
1134GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3679AAC39708.1Homo sapiens integrin alpha-7 mRNA, complete cds.HPRD02761
-1145NP_000071.1nicotinic acetylcholine receptor epsilon polypeptide precursorHPRD00008
-1146NP_005190.3cholinergic receptor, nicotinic, gamma polypeptideHPRD00009
NP_000070.1--Cholinergic receptor nicotinic delta polypeptideHPRD00007
NP_000070.1--Cholinergic receptor nicotinic beta polypeptideHPRD00007
NP_000070.11145-Nicotinic acetylcholine receptor, epsilon subunitHPRD00007
NP_000070.11146-Cholinergic receptor, nicotinic, gamma polypeptideHPRD00007
NP_000070.13679-Integrin alpha 7HPRD00007
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1134IPR001991Na/diCO_symportSodium:dicarboxylate symporter
1134IPR006201Neur_channelNeurotransmitter-gated ion-channel
1134IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
1134IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region
1134IPR002394Nic_ach_rcptNicotinic acetylcholine receptor
1134ACHA_HUMANP02708IPR001991Na/diCO_symportSodium:dicarboxylate symporter
1134ACHA_HUMANP02708IPR006201Neur_channelNeurotransmitter-gated ion-channel
1134ACHA_HUMANP02708IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
1134ACHA_HUMANP02708IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region
1134ACHA_HUMANP02708IPR002394Nic_ach_rcptNicotinic acetylcholine receptor

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