Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1136
Official Symbol:CHRNA3
Other Aliases:MGC104879
See related:HGNC:1957|MIM:118503|HPRD:07511
Chromosome:15
Location:15q24
Gene Description:cholinergic receptor, nicotinic, alpha 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0019
ORGANISM:human
Entrez Gene ID:1136
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:9489734
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:SH-SY5Y neuroblastoma cell line
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
110834CBCerebellum2.841446220874793.2768896818161
110834CTXCerebral cortex1.009167075157171.05439345538616
110834HIPHippocampal region1.007197931408881.14536977559328
110834HPFHippocampal formation0.8994586765766140.874126747250557
110834HYHypothalamus0.9843780100345611.01934589445591
110834LSXLateral septal complex0.5755915585905310.659143030643463
110834MBMidbrain4.89404416084294.64844417572021
110834MYMedulla2.990917801856994.09773993492126
110834OLFOlfactory bulb6.91818547248847.93925261497498
110834PPons1.6035355925562.89636063575745
110834PALPallidum0.8802320659160611.05424883961678
110834RHPRetrohippocampal region0.6164383441209790.417848758399487
110834sAMYStriatum-like amygdalar nuclei0.3510437011718750.340064391493797
110834STRStriatum0.5734230130910870.466335311532021
110834STRdStriatum dorsal region0.4194702208042140.371563151478767
110834STRvStriatum ventral region1.162196651101110.751379601657391
110834THThalamus2.597370743751534.20579826831818
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1136GO:0004889IEAFunctionnicotinic acetylcholine-activated cation-selective channel activity
1136GO:0004889TASFunctionnicotinic acetylcholine-activated cation-selective channel activity
1136GO:0005215TASFunctiontransporter activity
1136GO:0005216IEAFunctionion channel activity
1136GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
1136GO:0005892TASComponentnicotinic acetylcholine-gated receptor-channel complex
1136GO:0006811IEAProcession transport
1136GO:0007165TASProcesssignal transduction
1136GO:0015464TASFunctionacetylcholine receptor activity
1136GO:0016021IEAComponentintegral to membrane
1136GO:0030594IEAFunctionneurotransmitter receptor activity
1136GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1143NP_000741.1cholinergic receptor, nicotinic, beta polypeptide 4HPRD00337
NP_000734.21143-Cholinergic receptor neuronal nicotinic beta polypeptide 4HPRD07511
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1136ACHA3_HUMANP32297IPR006201Neur_channelNeurotransmitter-gated ion-channel
1136ACHA3_HUMANP32297IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
1136ACHA3_HUMANP32297IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region
1136ACHA3_HUMANP32297IPR002394Nic_ach_rcptNicotinic acetylcholine receptor

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