Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1137
Official Symbol:CHRNA4
Other Aliases:BFNC|EBN|EBN1|NACRA4
See related:HGNC:1958|MIM:118504|HPRD:00333
Chromosome:20
Location:20q13.2-q13.3
Gene Description:cholinergic receptor, nicotinic, alpha 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0116
ORGANISM:human
Entrez Gene ID:1137
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15154117
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0156
ORGANISM:human
Entrez Gene ID:1137
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15790597
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVID0004
ORGANISM:human
Entrez Gene ID:1137
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:118504
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11438CBCerebellum11.500667810440111.868212223053
11438CTXCerebral cortex28.30269813537622.6734161376953
11438HIPHippocampal region9.279361724853527.25218653678894
11438HPFHippocampal formation24.651235580444321.8828439712524
11438HYHypothalamus13.815135955810511.1152358055115
11438LSXLateral septal complex4.99962127208713.79926753044128
11438MBMidbrain35.239926338195837.7952728271484
11438MYMedulla26.933944702148430.0521745681763
11438OLFOlfactory bulb21.580540180206316.7454519271851
11438PPons32.008045196533234.7818412780762
11438PALPallidum6.439555168151865.84181904792786
11438RHPRetrohippocampal region50.811323165893642.3115711212158
11438sAMYStriatum-like amygdalar nuclei5.785515785217294.6937108039856
11438STRStriatum4.500881671905523.87432754039764
11438STRdStriatum dorsal region3.645089864730833.49156093597412
11438STRvStriatum ventral region5.227817296981813.4147207736969
11438THThalamus66.365802764892670.0810928344727
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1137GO:0004889IEAFunctionnicotinic acetylcholine-activated cation-selective channel activity
1137GO:0004889TASFunctionnicotinic acetylcholine-activated cation-selective channel activity
1137GO:0005216IEAFunctionion channel activity
1137GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
1137GO:0005892TASComponentnicotinic acetylcholine-gated receptor-channel complex
1137GO:0006811IEAProcession transport
1137GO:0007165TASProcesssignal transduction
1137GO:0007268TASProcesssynaptic transmission
1137GO:0007399TASProcessnervous system development
1137GO:0015464TASFunctionacetylcholine receptor activity
1137GO:0016021IEAComponentintegral to membrane
1137GO:0030594IEAFunctionneurotransmitter receptor activity
1137GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7447NP_003376.2visinin-like 1HPRD02890
NP_000735.17447-Visinin like 1HPRD00333
NP_000735.11141NP_000739.1cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)BIND296539
NP_000735.11143NP_000741.1cholinergic receptor, nicotinic, beta polypeptide 4HPRD00337
NP_000735.11143NP_000741.1cholinergic receptor, nicotinic, beta polypeptide 4HPRD00333
NP_000735.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00215
NP_000735.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00333
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1137ACHA4_HUMANP43681IPR006201Neur_channelNeurotransmitter-gated ion-channel
1137ACHA4_HUMANP43681IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
1137ACHA4_HUMANP43681IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region
1137ACHA4_HUMANP43681IPR002394Nic_ach_rcptNicotinic acetylcholine receptor
1137ACHA4_HUMANP43681IPR000694PRO_richProline-rich region

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