Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1139
Official Symbol:CHRNA7
Other Aliases:NACHRA7
See related:HGNC:1960|MIM:118511|HPRD:00339
Gene Description:cholinergic receptor, nicotinic, alpha 7
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
Entrez Gene ID:1139
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:9489734
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:SH-SY5Y neuroblastoma cell line
Drug Effects:
Fold Change:
KARG Evidence 2
Entrez Gene ID:1139
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1139GO:0000187TASProcessactivation of MAPK activity
1139GO:0004889TASFunctionnicotinic acetylcholine-activated cation-selective channel activity
1139GO:0005216IEAFunctionion channel activity
1139GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
1139GO:0005515IPIFunctionprotein binding
1139GO:0005892TASComponentnicotinic acetylcholine-gated receptor-channel complex
1139GO:0006811IEAProcession transport
1139GO:0007165NASProcesssignal transduction
1139GO:0007268NRProcesssynaptic transmission
1139GO:0015464TASFunctionacetylcholine receptor activity
1139GO:0016021IEAComponentintegral to membrane
1139GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000737.15295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD00339
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1139ACHA7_HUMANP36544IPR006201Neur_channelNeurotransmitter-gated ion-channel
1139ACHA7_HUMANP36544IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
1139ACHA7_HUMANP36544IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region
1139ACHA7_HUMANP36544IPR002394Nic_ach_rcptNicotinic acetylcholine receptor

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