Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:114
Official Symbol:ADCY8
Other Aliases:ADCY3|HBAC1
See related:HGNC:239|MIM:103070|HPRD:00051
Chromosome:8
Location:8q24
Gene Description:adenylate cyclase 8 (brain)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0020
ORGANISM:human
Entrez Gene ID:114
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:11514
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0389
ORGANISM:human
Entrez Gene ID:114
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29241
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11514CBCerebellum12.203124046325712.8382024765015
11514CTXCerebral cortex9.363962173461918.03096199035645
11514HIPHippocampal region5.856431007385258.02244472503662
11514HPFHippocampal formation14.441591262817416.4312171936035
11514HYHypothalamus2.055788993835451.76055562496185
11514LSXLateral septal complex0.5891764163970950.521820783615112
11514MBMidbrain3.612944126129154.02746391296387
11514MYMedulla8.998015403747568.82350826263428
11514OLFOlfactory bulb41.936740875244155.0486679077148
11514PPons9.111282348632819.36956691741943
11514PALPallidum2.850862979888922.71947932243347
11514RHPRetrohippocampal region30.401016235351629.7848320007324
11514sAMYStriatum-like amygdalar nuclei1.746167778968811.435302734375
11514STRStriatum0.7663465142250060.755435645580292
11514STRdStriatum dorsal region0.4532818198204040.458690226078033
11514STRvStriatum ventral region1.416274666786191.47949254512787
11514THThalamus17.20855331420915.0420951843262
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
114GO:0000287IEAFunctionmagnesium ion binding
114GO:0005624TASComponentmembrane fraction
114GO:0005886TASComponentplasma membrane
114GO:0006171IEAProcesscAMP biosynthesis
114GO:0007242IEAProcessintracellular signaling cascade
114GO:0007611TASProcesslearning and/or memory
114GO:0008294TASFunctioncalcium- and calmodulin-responsive adenylate cyclase activity
114GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001106.1--CalmodulinHPRD00051
NP_001106.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
114ADCY8_HUMANP40145IPR001054A/G_cyclaseAdenylyl cyclase class-3/4/guanylyl cyclase
114ADCY8_HUMANP40145IPR009398Aden_cycl_likeAdenylate cyclase-like
114ADCY8_HUMANP40145IPR000209Pept_S8_S53Peptidase S8 and S53, subtilisin, kexin, sedolisin

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