Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1146
Official Symbol:CHRNG
Other Aliases:ACHRG
See related:HGNC:1967|MIM:100730|HPRD:00009
Chromosome:2
Location:2q33-q34
Gene Description:cholinergic receptor, nicotinic, gamma
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0011
ORGANISM:human
Entrez Gene ID:1146
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11449CBCerebellum3.44144219160083.94408756494522
11449CTXCerebral cortex1.476376548409461.68510672450066
11449HIPHippocampal region0.8232075124979020.949775159358978
11449HPFHippocampal formation0.762144744396210.851672232151031
11449HYHypothalamus0.2920583486557010.208435080945492
11449LSXLateral septal complex0.1687617488205430.189848482608795
11449MBMidbrain0.551862657070160.622652679681778
11449MYMedulla1.832596719264982.06608945131302
11449OLFOlfactory bulb2.265343859791762.2233961224556
11449PPons0.8470266163349150.891472965478897
11449PALPallidum0.6945748925209050.748456165194511
11449RHPRetrohippocampal region0.6476914286613460.722452938556671
11449sAMYStriatum-like amygdalar nuclei0.5851621031761170.497104749083519
11449STRStriatum0.8316098451614380.64633683860302
11449STRdStriatum dorsal region1.031661503016950.824056379497051
11449STRvStriatum ventral region0.4681935310363770.277845866978168
11449THThalamus0.7902418971061710.784233421087265
KARG Evidence 2
KARG ID:QTL0011
Trait:cocaine related behavior
Peak:52.3
Peak Marker:Chrng
Parents:BXD/Ty (B = C57BL/6, D = DBA/2) recombinant inbred
Evidence ID:10591541
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1146GO:0004889IEAFunctionnicotinic acetylcholine-activated cation-selective channel activity
1146GO:0004981NRFunctionmuscarinic acetylcholine receptor activity
1146GO:0005216IEAFunctionion channel activity
1146GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
1146GO:0005887TASComponentintegral to plasma membrane
1146GO:0006811IEAProcession transport
1146GO:0006936TASProcessmuscle contraction
1146GO:0007165TASProcesssignal transduction
1146GO:0015267TASFunctionchannel or pore class transporter activity
1146GO:0016021IEAComponentintegral to membrane
1146GO:0030594IEAFunctionneurotransmitter receptor activity
1146GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1146ACHG_HUMANP07510IPR006201Neur_channelNeurotransmitter-gated ion-channel
1146ACHG_HUMANP07510IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
1146ACHG_HUMANP07510IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region
1146ACHG_HUMANP07510IPR002394Nic_ach_rcptNicotinic acetylcholine receptor

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