Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:114876
Official Symbol:OSBPL1A
Other Aliases:FLJ10217|ORP1|OSBPL1B
See related:HGNC:16398|MIM:606730|HPRD:09472
Chromosome:18
Location:18q11.1
Gene Description:oxysterol binding protein-like 1A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0094
ORGANISM:human
Entrez Gene ID:114876
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.30 :: -0.39 :: -0.72 :: -0.75 :: -0.44 :: 0.09 :: -0.34 :: -0.06 :: -0.34 :: -0.82
KARG Evidence 2
KARG ID:HOT0283
ORGANISM:human
Entrez Gene ID:114876
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:HOT0325
ORGANISM:human
Entrez Gene ID:114876
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
64291CBCerebellum0.5435988306999210.919629037380219
64291CTXCerebral cortex0.4041315019130710.723300993442535
64291HIPHippocampal region0.5357206463813780.756117701530457
64291HPFHippocampal formation0.3974687159061430.533798217773438
64291HYHypothalamus0.1720626652240750.171231999993324
64291LSXLateral septal complex0.1313576549291610.108264841139317
64291MBMidbrain0.202120855450630.340573877096176
64291MYMedulla1.371290564537051.98287332057953
64291OLFOlfactory bulb0.1263902932405470.170187816023827
64291PPons0.319038003683090.333784222602844
64291PALPallidum0.1186394318938260.140646353363991
64291RHPRetrohippocampal region0.1697818636894230.231401696801186
64291sAMYStriatum-like amygdalar nuclei0.0273083522915840.0
64291STRStriatum0.3979397118091580.506880402565002
64291STRdStriatum dorsal region0.1073487401008610.177501142024994
64291STRvStriatum ventral region1.683351397514341.81023299694061
64291THThalamus0.338234990835190.446203351020813
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
114876GO:0005543NASFunctionphospholipid binding
114876GO:0005622ICComponentintracellular
114876GO:0006869IEAProcesslipid transport
114876GO:0008202IEAProcesssteroid metabolism
114876GO:0008203NASProcesscholesterol metabolism
114876GO:0016192NASProcessvesicle-mediated transport
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
114876IPR000648Oxysterol_bdOxysterol-binding protein
114876OSBL1_HUMANQ9BXW6IPR002110ANKAnkyrin
114876OSBL1_HUMANQ9BXW6IPR000648Oxysterol_bdOxysterol-binding protein
114876OSBL1_HUMANQ9BXW6IPR001849PHPleckstrin-like
114876OSBL1_HUMANQ9BXW6IPR013555TRP_2Transient receptor ion channel II

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