Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1175
Official Symbol:AP2S1
Other Aliases:AP17|AP17-DELTA|CLAPS2
See related:HGNC:565|MIM:602242|HPRD:03762
Chromosome:19
Location:19q13.2-q13.3
Gene Description:adaptor-related protein complex 2, sigma 1 subunit
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0064
ORGANISM:human
Entrez Gene ID:1175
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:0.11 :: -0.15 :: 0.12 :: -0.05 :: -0.44 :: 0.09 :: -0.49 :: -0.60 :: -0.42 :: -0.91
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
232910CBCerebellum35.976303100585976.9980945587158
232910CTXCerebral cortex100.0100.0
232910HIPHippocampal region91.5176887512207100.0
232910HPFHippocampal formation99.2696418762207100.0
232910HYHypothalamus100.0100.0
232910LSXLateral septal complex100.098.037540435791
232910MBMidbrain92.886131286621199.1415176391602
232910MYMedulla64.917747497558691.8469886779785
232910OLFOlfactory bulb100.0100.0
232910PPons76.306983947753995.9258766174316
232910PALPallidum94.223560333252100.0
232910RHPRetrohippocampal region100.0100.0
232910sAMYStriatum-like amygdalar nuclei100.0100.0
232910STRStriatum95.640106201171988.2113647460938
232910STRdStriatum dorsal region86.917987823486376.2617034912109
232910STRvStriatum ventral region100.090.3540878295898
232910THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1175GO:0000004NDProcessbiological process unknown
1175GO:0005554NDFunctionmolecular function unknown
1175GO:0005905IEAComponentcoated pit
1175GO:0006810IEAProcesstransport
1175GO:0006886IEAProcessintracellular protein transport
1175GO:0008372NDComponentcellular component unknown
1175GO:0008565NASFunctionprotein transporter activity
1175GO:0030100TASProcessregulation of endocytosis
1175GO:0030122TASComponentAP-2 adaptor complex
1175GO:0030125IEAComponentclathrin vesicle coat
1175GO:0048268TASProcessclathrin cage assembly
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_004060.1--Alpha-adaptinHPRD03762
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1175IPR000804Clat_adaptor_sClathrin adaptor complex, small chain
1175AP2S1_HUMANP53680IPR000804Clat_adaptor_sClathrin adaptor complex, small chain

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