Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1182
Official Symbol:CLCN3
Other Aliases:CLC3|ClC-3
See related:HGNC:2021|MIM:600580|HPRD:02785
Chromosome:4
Location:4q33
Gene Description:chloride channel 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0044
ORGANISM:human
Entrez Gene ID:1182
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12725
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12725CBCerebellum71.1037673950195100.0
12725CTXCerebral cortex100.0100.0
12725HIPHippocampal region100.0100.0
12725HPFHippocampal formation100.0100.0
12725HYHypothalamus100.0100.0
12725LSXLateral septal complex97.098556518554789.0529251098633
12725MBMidbrain100.0100.0
12725MYMedulla93.8520736694336100.0
12725OLFOlfactory bulb100.0100.0
12725PPons83.8022613525391100.0
12725PALPallidum97.7531967163086100.0
12725RHPRetrohippocampal region100.0100.0
12725sAMYStriatum-like amygdalar nuclei100.0100.0
12725STRStriatum100.0100.0
12725STRdStriatum dorsal region100.0100.0
12725STRvStriatum ventral region100.0100.0
12725THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5174NP_002605.2PDZ domain containing 1HPRD04829
NP_001820.15174-PDZK1HPRD02785
NP_001820.11182NP_001820.1chloride channel 3HPRD02785
NP_001820.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD05406
NP_001820.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD02785
NP_001820.25174-CLAMPHPRD02785
NP_001820.21182NP_001820.2chloride channel 3 isoform bHPRD02785
NP_001820.29368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD02785
NP_001820.257120NP_065132.1golgi associated PDZ and coiled-coil motif containing isoform aHPRD02785
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1182IPR000644CBSCBS
1182IPR001807Cl-channel_voltCl- channel, voltage gated
1182IPR002245Cl_channel3Chloride channel CLC-3
1182CLCN3_HUMANP51790IPR000644CBSCBS
1182CLCN3_HUMANP51790IPR001807Cl-channel_voltCl- channel, voltage gated
1182CLCN3_HUMANP51790IPR002245Cl_channel3Chloride channel CLC-3

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