Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1183
Official Symbol:CLCN4
Other Aliases:CLC4|ClC-4|ClC-4A
See related:HGNC:2022|MIM:302910|HPRD:02362
Chromosome:X
Location:Xp22.3
Gene Description:chloride channel 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0284
ORGANISM:human
Entrez Gene ID:1183
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.54
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12727CBCerebellum27.482547760009847.7037353515625
12727CTXCerebral cortex90.691596984863389.7247695922852
12727HIPHippocampal region47.06822967529394.7351913452148
12727HPFHippocampal formation63.439857482910293.4478378295898
12727HYHypothalamus11.033288002014210.5052127838135
12727LSXLateral septal complex27.144409179687525.8156337738037
12727MBMidbrain18.482192993164121.7240581512451
12727MYMedulla42.587905883789158.3480949401855
12727OLFOlfactory bulb73.698822021484482.5098495483398
12727PPons28.069316864013739.2115020751953
12727PALPallidum21.691913604736325.097297668457
12727RHPRetrohippocampal region91.891006469726697.1222991943359
12727sAMYStriatum-like amygdalar nuclei29.118637084960926.338228225708
12727STRStriatum23.956790924072321.9439353942871
12727STRdStriatum dorsal region19.572181701660217.9749755859375
12727STRvStriatum ventral region34.751449584960930.0132369995117
12727THThalamus40.434406280517645.847900390625
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1183GO:0005247IEAFunctionvoltage-gated chloride channel activity
1183GO:0005247TASFunctionvoltage-gated chloride channel activity
1183GO:0005624NRComponentmembrane fraction
1183GO:0005887NRComponentintegral to plasma membrane
1183GO:0006811IEAProcession transport
1183GO:0006821IDAProcesschloride transport
1183GO:0006821IEAProcesschloride transport
1183GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1183CLCN4_HUMANP51793IPR000644CBSCBS
1183CLCN4_HUMANP51793IPR001807Cl-channel_voltCl- channel, voltage gated
1183CLCN4_HUMANP51793IPR002246Cl_channel4Chloride channel CLC-4

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