Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1191
Official Symbol:CLU
Other Aliases:AAG4|APOJ|CLI|KUB1|MGC24903|SGP-2|SGP2|SP-40|TRPM-2|TRPM2
See related:HGNC:2095|MIM:185430|HPRD:01706
Chromosome:8
Location:8p21-p12
Gene Description:clusterin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0976
ORGANISM:human
Entrez Gene ID:1191
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.3 :: -1.7 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12759CBCerebellum51.688001632690457.4942140579224
12759CTXCerebral cortex68.271648406982460.7199602127075
12759HIPHippocampal region87.849094390869191.4476356506348
12759HPFHippocampal formation89.611343383789188.6183204650879
12759HYHypothalamus64.028250694274957.1954793930054
12759LSXLateral septal complex95.478542327880994.2222442626953
12759MBMidbrain57.201591491699258.3152332305908
12759MYMedulla62.645339965820376.5908622741699
12759OLFOlfactory bulb84.159889221191474.7446708679199
12759PPons59.983745574951271.4342079162598
12759PALPallidum51.05746650695845.5292110443115
12759RHPRetrohippocampal region90.930858612060583.7028999328613
12759sAMYStriatum-like amygdalar nuclei82.270851135253980.1806259155273
12759STRStriatum77.773000717163174.808349609375
12759STRdStriatum dorsal region73.813505172729571.4417991638184
12759STRvStriatum ventral region77.137306213378965.7090244293213
12759THThalamus46.812151908874549.9806308746338
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1191GO:0005576NASComponentextracellular region
1191GO:0006629NASProcesslipid metabolism
1191GO:0006915IEAProcessapoptosis
1191GO:0006958IEAProcesscomplement activation, classical pathway
1191GO:0007338NRProcessfertilization (sensu Metazoa)
1191GO:0008219IEAProcesscell death
1191GO:0045087IEAProcessinnate immune response
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3953NP_002294.1leptin receptorHPRD03001
-7436NP_003374.1very low density lipoprotein receptorHPRD01895
-7804NP_004622.1low density lipoprotein receptor-related protein 8 isoform 1 precursorHPRD04002
NP_001822.1--Amyloid beta Protein 1HPRD01706
NP_001822.13953-Leptin receptorHPRD01706
NP_001822.17436-VLDL receptorHPRD01706
NP_001822.17804-APOER2HPRD01706
NP_001822.13952NP_000221.1leptin precursorHPRD01249
NP_001822.13952NP_000221.1leptin precursorHPRD01706
NP_001822.15444NP_000437.3paraoxonase 1HPRD01706
NP_001822.12547NP_001460.1ATP-dependent DNA helicase II, 70 kDa subunitHPRD01071
NP_001822.12547NP_001460.1ATP-dependent DNA helicase II, 70 kDa subunitHPRD01706
NP_001822.11191NP_001822.1clusterinHPRD01706
NP_001822.17048NP_003233.2transforming growth factor, beta receptor II (70/80kDa)HPRD01706
NP_001822.17048NP_003233.2transforming growth factor, beta receptor II (70/80kDa)HPRD01823
NP_001822.14036NP_004516.1low density lipoprotein-related protein 2HPRD02509
NP_001822.14036NP_004516.1low density lipoprotein-related protein 2HPRD01706
NP_001822.17046NP_004603.1transforming growth factor, beta receptor I precursorHPRD01706
NP_001822.17046NP_004603.1transforming growth factor, beta receptor I precursorHPRD01822
NP_001822.164386NP_071913.1matrix metalloproteinase 25 preproproteinHPRD07090
NP_001822.164386NP_071913.1matrix metalloproteinase 25 preproproteinHPRD01706
NP_001822.2--Amyloid beta Protein 1HPRD01706
NP_001822.23953-Leptin receptorHPRD01706
NP_001822.27436-VLDL receptorHPRD01706
NP_001822.27804-APOER2HPRD01706
NP_001822.23952NP_000221.1leptin precursorHPRD01706
NP_001822.25621NP_000302.1prion protein preproproteinHPRD01706
NP_001822.25444NP_000437.3paraoxonase 1HPRD01706
NP_001822.22547NP_001460.1ATP-dependent DNA helicase II, 70 kDa subunitHPRD01706
NP_001822.21191NP_001822.2clusterin isoform 1HPRD01706
NP_001822.27048NP_003233.2transforming growth factor, beta receptor II (70/80kDa)HPRD01706
NP_001822.24036NP_004516.1low density lipoprotein-related protein 2HPRD01706
NP_001822.27046NP_004603.1transforming growth factor, beta receptor I precursorHPRD01706
NP_001822.264386NP_071913.1matrix metalloproteinase 25 preproproteinHPRD01706
NP_976084.123059BAD44779.1clusterin associated protein 1BIND185091
NP_976084.12547NP_001460.1ATP-dependent DNA helicase II, 70 kDa subunitBIND259446
NP_976084.17048NP_003233.3transforming growth factor, beta receptor IIBIND149072
NP_976084.17046NP_004603.1transforming growth factor, beta receptor I precursorBIND149073
NP_976084.11191NP_976084.1clusterin isoform 2BIND262393
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1191CLUS_HUMANP10909IPR000753ClusterinClusterin

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