Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1195
Official Symbol:CLK1
Other Aliases:CLK|CLK/STY|STY
See related:HGNC:2068|MIM:601951|HPRD:09058
Chromosome:2
Location:2q33
Gene Description:CDC-like kinase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0886
ORGANISM:human
Entrez Gene ID:1195
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12747CBCerebellum96.300048828125100.0
12747CTXCerebral cortex100.0100.0
12747HIPHippocampal region100.0100.0
12747HPFHippocampal formation100.0100.0
12747HYHypothalamus100.0100.0
12747LSXLateral septal complex100.0100.0
12747MBMidbrain100.0100.0
12747MYMedulla100.0100.0
12747OLFOlfactory bulb100.0100.0
12747PPons100.0100.0
12747PALPallidum100.0100.0
12747RHPRetrohippocampal region100.0100.0
12747sAMYStriatum-like amygdalar nuclei100.0100.0
12747STRStriatum100.0100.0
12747STRdStriatum dorsal region100.0100.0
12747STRvStriatum ventral region100.098.0820693969727
12747THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1195GO:0000074TASProcessregulation of progression through cell cycle
1195GO:0000166IEAFunctionnucleotide binding
1195GO:0004674IEAFunctionprotein serine/threonine kinase activity
1195GO:0004674TASFunctionprotein serine/threonine kinase activity
1195GO:0004715TASFunctionnon-membrane spanning protein tyrosine kinase activity
1195GO:0005524IEAFunctionATP binding
1195GO:0005634IEAComponentnucleus
1195GO:0006468IEAProcessprotein amino acid phosphorylation
1195GO:0008283TASProcesscell proliferation
1195GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4155NP_002376.1myelin basic protein isoform 2HPRD01158
NP_004062.1--Histone H1HPRD09058
NP_004062.1--CaseinHPRD09058
NP_004062.1--Histone VIIIHPRD09058
NP_004062.1--LUC7AHPRD09058
NP_004062.1--Ubl5HPRD09058
NP_004062.16426-Splicing factor, arginine/serine rich 1HPRD09058
NP_004062.14155-Myelin basic proteinHPRD09058
NP_004062.19128-PRP4HPRD09058
NP_004062.19360NP_004783.2peptidyl-prolyl isomerase G (cyclophilin G)BIND58074
NP_004062.16431NP_006266.2arginine/serine-rich splicing factor 6HPRD09054
NP_004062.16431NP_006266.2arginine/serine-rich splicing factor 6HPRD09058
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1195IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1195IPR000719Prot_kinaseProtein kinase
1195IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
1195IPR013695WAKWall-associated kinase
1195CLK1_HUMANP49759IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1195CLK1_HUMANP49759IPR000719Prot_kinaseProtein kinase
1195CLK1_HUMANP49759IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
1195CLK1_HUMANP49759IPR013695WAKWall-associated kinase

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