Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1196
Official Symbol:CLK2
Other Aliases:MGC61500|hCLK2
See related:HGNC:2069|MIM:602989|HPRD:04289
Chromosome:1
Location:1q21
Gene Description:CDC-like kinase 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0885
ORGANISM:human
Entrez Gene ID:1196
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.5 :: -1.1 :: -1.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12748CBCerebellum53.41350173950285.9473609924316
12748CTXCerebral cortex100.0100.0
12748HIPHippocampal region87.5902786254883100.0
12748HPFHippocampal formation93.2501983642578100.0
12748HYHypothalamus83.327484130859478.211404800415
12748LSXLateral septal complex100.0100.0
12748MBMidbrain81.698760986328182.2739791870117
12748MYMedulla85.699440002441492.602855682373
12748OLFOlfactory bulb100.0100.0
12748PPons81.39188194274985.0836524963379
12748PALPallidum82.115318298339884.640567779541
12748RHPRetrohippocampal region100.0100.0
12748sAMYStriatum-like amygdalar nuclei100.097.7089080810547
12748STRStriatum98.527160644531289.2754936218262
12748STRdStriatum dorsal region95.87688064575287.1335258483887
12748STRvStriatum ventral region96.821220397949286.157886505127
12748THThalamus93.556694030761792.6160507202148
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1196GO:0000166IEAFunctionnucleotide binding
1196GO:0004674IEAFunctionprotein serine/threonine kinase activity
1196GO:0004674TASFunctionprotein serine/threonine kinase activity
1196GO:0004713IEAFunctionprotein-tyrosine kinase activity
1196GO:0005524IEAFunctionATP binding
1196GO:0005634IEAComponentnucleus
1196GO:0006468IEAProcessprotein amino acid phosphorylation
1196GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003984.17532NP_036611.2tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideHPRD04289
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1196IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1196IPR000719Prot_kinaseProtein kinase
1196IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
1196IPR013695WAKWall-associated kinase
1196CLK2_HUMANP49760IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1196CLK2_HUMANP49760IPR000719Prot_kinaseProtein kinase
1196CLK2_HUMANP49760IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
1196CLK2_HUMANP49760IPR013695WAKWall-associated kinase

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