Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:12
Official Symbol:SERPINA3
Other Aliases:AACT|ACT|GIG24|GIG25|MGC88254
See related:HGNC:16|MIM:107280|HPRD:00120
Chromosome:14
Location:14q32.1
Gene Description:serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0080
ORGANISM:human
Entrez Gene ID:12
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20716
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
74069CBCerebellum0.3125434517860410.603632569313049
20716CBCerebellum0.6672052145004271.20613405108452
16625CBCerebellum0.9841404259204861.57074594497681
238393CBCerebellum1.018665671348571.36083018779755
271047CBCerebellum5.612213134765627.45234966278076
74069CTXCerebral cortex0.3482752442359920.411097258329391
20716CTXCerebral cortex0.7059017419815060.762700021266937
238393CTXCerebral cortex0.7793017625808721.22061693668365
271047CTXCerebral cortex0.7913005352020261.02196633815765
16625CTXCerebral cortex2.38049569725992.48538118600845
74069HIPHippocampal region0.3111612796783450.520190060138702
238393HIPHippocampal region0.5187614560127260.848571598529816
271047HIPHippocampal region0.6469869613647461.0304388999939
20716HIPHippocampal region1.003589868545530.986590415239334
16625HIPHippocampal region10.534295082092315.1752667427063
74069HPFHippocampal formation0.3099612295627590.546095848083496
238393HPFHippocampal formation0.4263505637645720.61549437046051
271047HPFHippocampal formation0.5228723883628850.998549461364746
20716HPFHippocampal formation0.7634984254837040.707880780100822
16625HPFHippocampal formation7.584249258041389.77624535560608
271047HYHypothalamus0.03169588744640350.0166769307106733
238393HYHypothalamus0.08464958518743520.134588912129402
74069HYHypothalamus0.1218872293829920.304065257310867
20716HYHypothalamus0.8734357655048370.627453416585922
16625HYHypothalamus4.103468179702764.24347233772278
271047LSXLateral septal complex0.03804069012403490.0
238393LSXLateral septal complex0.06451251357793810.0509440302848816
20716LSXLateral septal complex0.1204761490225790.0627123359590769
74069LSXLateral septal complex0.1825288087129590.160509094595909
16625LSXLateral septal complex0.4581508636474610.532182261347771
74069MBMidbrain0.2021526694297790.331214338541031
271047MBMidbrain0.3197345435619350.488010346889496
20716MBMidbrain0.4003901928663250.360994502902031
238393MBMidbrain0.4599255919456480.7318976521492
16625MBMidbrain2.636694639921192.50704747438431
271047MYMedulla0.5329132080078120.603167533874512
20716MYMedulla0.8715858161449430.529119670391083
74069MYMedulla1.172096729278562.18978238105774
238393MYMedulla1.468274354934691.87454473972321
16625MYMedulla7.103537559509288.9016375541687
74069OLFOlfactory bulb0.3497529029846190.435095369815826
20716OLFOlfactory bulb0.4636386930942540.424291409552097
271047OLFOlfactory bulb2.139827966690061.91867482662201
16625OLFOlfactory bulb2.172528803348542.90349555015564
238393OLFOlfactory bulb2.51878285408024.84965181350708
271047PPons0.2076937109231950.345531582832336
74069PPons0.338928848505020.485121250152588
238393PPons0.4094182848930360.504086554050446
20716PPons0.5972532778978350.50005042552948
16625PPons6.910923600196847.30287063121796
271047PALPallidum0.04381676763296130.0257139801979065
238393PALPallidum0.07933266460895540.142857760190964
74069PALPallidum0.3148092031478880.360123813152313
20716PALPallidum0.4052992835640910.374591864645481
16625PALPallidum1.14386414363980.882636971771717
74069RHPRetrohippocampal region0.2544955313205720.481917589902878
271047RHPRetrohippocampal region0.2566719651222230.692782282829285
238393RHPRetrohippocampal region0.2796528339385990.306317299604416
20716RHPRetrohippocampal region0.3435404151678090.22819297760725
16625RHPRetrohippocampal region2.901759028434752.54265213012695
271047sAMYStriatum-like amygdalar nuclei0.03120533376932140.0
238393sAMYStriatum-like amygdalar nuclei0.03538759052753450.0
20716sAMYStriatum-like amygdalar nuclei0.3029491454362870.24031376093626
74069sAMYStriatum-like amygdalar nuclei0.4623525142669680.832380175590515
16625sAMYStriatum-like amygdalar nuclei0.7674939334392550.66948264837265
238393STRStriatum0.158269032835960.270346850156784
74069STRStriatum0.2731563746929170.390697747468948
16625STRStriatum0.3828433528542520.331256501376629
20716STRStriatum0.8805043846368790.928298272192478
271047STRStriatum1.44755315780641.82229459285736
238393STRdStriatum dorsal region0.2233843654394150.253732144832611
74069STRdStriatum dorsal region0.2903529107570650.440710544586182
16625STRdStriatum dorsal region0.3240717276930810.27820248156786
20716STRdStriatum dorsal region1.222776651382451.35050552338362
271047STRdStriatum dorsal region2.295477628707892.97585344314575
238393STRvStriatum ventral region0.04190221801400180.578247845172882
271047STRvStriatum ventral region0.1303556710481640.105914667248726
74069STRvStriatum ventral region0.1383526772260670.103850737214088
16625STRvStriatum ventral region0.2541288770735260.174649374559522
20716STRvStriatum ventral region0.3098660856485370.286726787686348
74069THThalamus0.2224611937999730.307592988014221
271047THThalamus0.3340406119823460.326851278543472
238393THThalamus0.457965373992920.549450933933258
20716THThalamus0.4643928036093710.578136213123798
16625THThalamus1.561980739235881.53424781560898
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
12GO:0003677ICFunctionDNA binding
12GO:0005515IPIFunctionprotein binding
12GO:0005576NASComponentextracellular region
12GO:0005622NASComponentintracellular
12GO:0006953IEAProcessacute-phase response
12GO:0006954NASProcessinflammatory response
12GO:0019216NASProcessregulation of lipid metabolism
12GO:0030569NASFunctionchymotrypsin inhibitor activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001076.1--DefensinHPRD00120
NP_001076.1--Thiol proteaseHPRD00120
NP_001076.1--ChymotrypsinHPRD00120
NP_001076.12153NP_000121.1coagulation factor V precursorHPRD01964
NP_001076.12153NP_000121.1coagulation factor V precursorHPRD00120
NP_001076.1351NP_000475.1amyloid beta A4 protein precursor, isoform aHPRD00100
NP_001076.1351NP_000475.1amyloid beta A4 protein precursor, isoform aHPRD00120
NP_001076.1354NP_001639.1prostate specific antigen isoform 1 preproproteinHPRD00120
NP_001076.11215NP_001827.1chymase 1, mast cell preproproteinHPRD00346
NP_001076.11215NP_001827.1chymase 1, mast cell preproproteinHPRD00120
NP_001076.11504NP_001897.1chymotrypsinogen B1HPRD00345
NP_001076.11504NP_001897.1chymotrypsinogen B1HPRD00120
NP_001076.11506NP_001898.1chymotrypsin-likeHPRD00120
NP_001076.11506NP_001898.1chymotrypsin-likeHPRD00344
NP_001076.11511NP_001902.1cathepsin G preproproteinHPRD00120
NP_001076.11511NP_001902.1cathepsin G preproproteinHPRD00289
NP_001076.11511NP_001902.1cathepsin G preproproteinBIND149291
NP_001076.11990NP_001962.2elastase 1, pancreaticHPRD00120
NP_001076.11990NP_001962.2elastase 1, pancreaticHPRD00553
NP_001076.11991NP_001963.1elastase 2, neutrophil preproproteinHPRD00554
NP_001076.11991NP_001963.1elastase 2, neutrophil preproproteinHPRD00120
NP_001076.14035NP_002323.1low density lipoprotein-related protein 1BIND149296
NP_001076.12064NP_004439.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologHPRD01281
NP_001076.12064NP_004439.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologHPRD00120
NP_001076.13817NP_005542.1kallikrein 2, prostatic isoform 1HPRD01006
NP_001076.13817NP_005542.1kallikrein 2, prostatic isoform 1HPRD00120
NP_001076.15422NP_058633.1polymerase (DNA-directed), alphaHPRD00120
NP_001076.15422NP_058633.1polymerase (DNA-directed), alphaHPRD02416
NP_001076.14485NP_066278.2macrophage stimulating 1 (hepatocyte growth factor-like)HPRD00798
NP_001076.14485NP_066278.2macrophage stimulating 1 (hepatocyte growth factor-like)HPRD00120
NP_001076.164215NP_071760.2DnaJ (Hsp40) homolog, subfamily C, member 1HPRD09922
NP_001076.164215NP_071760.2DnaJ (Hsp40) homolog, subfamily C, member 1HPRD00120
NP_001076.2351NP_000475.1amyloid beta A4 protein precursor, isoform aHPRD00100
NP_001076.2354NP_001639.1prostate specific antigen isoform 1 preproproteinHPRD01461
NP_001076.22064NP_004439.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologHPRD01281
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
12AACT_HUMANP01011IPR000295Prot_inh_Lserp2Proteinase inhibitor I4, leuserpin 2
12AACT_HUMANP01011IPR000215Prot_inh_serpinProteinase inhibitor I4, serpin

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