Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1212
Official Symbol:CLTB
Other Aliases:LCB
See related:HGNC:2091|MIM:118970|HPRD:00352
Chromosome:5
Location:4q2-q3|5q35
Gene Description:clathrin, light polypeptide (Lcb)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0065
ORGANISM:human
Entrez Gene ID:1212
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:0.24 :: -0.35 :: 0.31 :: 0.07 :: -0.46 :: 0.28 :: -0.43 :: -0.34 :: -0.54 :: -0.39
KARG Evidence 2
KARG ID:EVIM0112
ORGANISM:human
Entrez Gene ID:1212
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:3.11 :: 2.97 :: 6.40 :: 2.77 :: -3.54 :: -3.15 :: -1.51
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
74325CBCerebellum10.988728523254412.7278661727905
74325CTXCerebral cortex30.551300048828122.3373508453369
74325HIPHippocampal region16.238142013549815.190336227417
74325HPFHippocampal formation21.358879089355518.0651454925537
74325HYHypothalamus7.662389755249026.4005069732666
74325LSXLateral septal complex3.026266098022462.64435029029846
74325MBMidbrain13.115510940551814.0018033981323
74325MYMedulla34.100536346435543.2271308898926
74325OLFOlfactory bulb29.473125457763725.2032470703125
74325PPons21.210624694824226.524829864502
74325PALPallidum18.760190963745120.0834636688232
74325RHPRetrohippocampal region31.84194755554223.4088649749756
74325sAMYStriatum-like amygdalar nuclei10.17812728881847.54240942001343
74325STRStriatum11.33241462707528.63651943206787
74325STRdStriatum dorsal region11.82198047637949.07212257385254
74325STRvStriatum ventral region14.020455360412610.169469833374
74325THThalamus20.081651687622117.3970355987549
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1212GO:0005509IEAFunctioncalcium ion binding
1212GO:0005554NDFunctionmolecular function unknown
1212GO:0005905IEAComponentcoated pit
1212GO:0006886NASProcessintracellular protein transport
1212GO:0030125IEAComponentclathrin vesicle coat
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9026NP_003950.1huntingtin interacting protein-1-relatedHPRD10412
-3092NP_005329.3huntingtin interacting protein 1HPRD03461
NP_009028.1--HIP12HPRD00352
NP_009028.1--CalmodulinHPRD00352
NP_009028.13092-HIP1HPRD00352
NP_009028.19026-Huntingtin interacting protein 12HPRD00352
NP_009028.11213NP_004850.1clathrin heavy chain 1HPRD00350
NP_009028.11213NP_004850.1clathrin heavy chain 1HPRD00352
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1212IPR000996Clathrin_lg_chClathrin light chain
1212CLCB_HUMANP09497IPR000996Clathrin_lg_chClathrin light chain

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