Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1230
Official Symbol:CCR1
Other Aliases:CD191|CKR-1|CMKBR1|HM145|MIP1aR|SCYAR1
See related:HGNC:1602|MIM:601159|HPRD:03101
Chromosome:3
Location:3p21
Gene Description:chemokine (C-C motif) receptor 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0396
ORGANISM:human
Entrez Gene ID:1230
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.3 :: -1.6 :: -1.2 :: -1.4 :: -1.6 :: -1.8
KARG Evidence 2
KARG ID:EVIM0464
ORGANISM:human
Entrez Gene ID:1230
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.7 :: -1.6 :: -1.5 :: -2.5 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12768CBCerebellum60.318946838378995.7335624694824
12768CTXCerebral cortex99.633148193359491.8384284973145
12768HIPHippocampal region86.656005859375100.0
12768HPFHippocampal formation92.0478744506836100.0
12768HYHypothalamus61.11889648437553.5180168151855
12768LSXLateral septal complex72.336729049682668.5331535339355
12768MBMidbrain72.180767059326274.3054008483887
12768MYMedulla88.350006103515691.8245315551758
12768OLFOlfactory bulb90.780452728271583.5120391845703
12768PPons81.696317672729583.744068145752
12768PALPallidum74.558551788330177.4934272766113
12768RHPRetrohippocampal region100.095.4279022216797
12768sAMYStriatum-like amygdalar nuclei79.7084960937565.5325222015381
12768STRStriatum79.919853210449268.0810565948486
12768STRdStriatum dorsal region78.159137725830166.5064888000488
12768STRvStriatum ventral region84.056320190429768.8594799041748
12768THThalamus73.831321716308673.268684387207
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1230GO:0001584IEAFunctionrhodopsin-like receptor activity
1230GO:0004872IEAFunctionreceptor activity
1230GO:0005515IPIFunctionprotein binding
1230GO:0005886IDAComponentplasma membrane
1230GO:0005887TASComponentintegral to plasma membrane
1230GO:0006935NASProcesschemotaxis
1230GO:0006954TASProcessinflammatory response
1230GO:0007155TASProcesscell adhesion
1230GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
1230GO:0007204TASProcesselevation of cytosolic calcium ion concentration
1230GO:0007267TASProcesscell-cell signaling
1230GO:0016493IEAFunctionC-C chemokine receptor activity
1230GO:0019221NASProcesscytokine and chemokine mediated signaling pathway
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6354CAA50405.1monocyte chemoattractant protein (MCP-3)HPRD01150
-6348NP_002974.1chemokine (C-C motif) ligand 3HPRD01656
-6352NP_002976.2small inducible cytokine A5 precursorHPRD01751
-6360NP_004581.1small inducible cytokine A16 precursorHPRD03233
-6349NP_066286.1chemokine (C-C motif) ligand 3-like 1 precursorHPRD03234
-6358NP_116738.1chemokine (C-C motif) ligand 14 isoform 2 precursorHPRD03231
NP_001286.16354-Monocyte chemotactic protein 3HPRD03101
NP_001286.16352-CCL5HPRD03101
NP_001286.16348-CCL3HPRD03101
NP_001286.16360-CCL16HPRD03101
NP_001286.16358-CCL14HPRD03101
NP_001286.16349-Chemokine, CC motif, ligand 3 like protein 1HPRD03101
NP_001286.15355NP_002659.1proteolipid protein 2 (colonic epithelium-enriched)BIND183282
NP_001286.19630NP_004288.1guanine nucleotide binding protein (G protein), alpha 14HPRD05095
NP_001286.19630NP_004288.1guanine nucleotide binding protein (G protein), alpha 14HPRD03101
NP_001286.16368NP_005055.2small inducible cytokine A23 isoform CKbeta8-1 precursorHPRD03930
NP_001286.16368NP_005055.2small inducible cytokine A23 isoform CKbeta8-1 precursorHPRD03101
NP_001286.16355NP_005614.2small inducible cytokine A8 precursorHPRD03791
NP_001286.16355NP_005614.2small inducible cytokine A8 precursorHPRD03101
NP_001286.16359NP_116741.1chemokine (C-C motif) ligand 15 precursorHPRD03101
NP_001286.16359NP_116741.1chemokine (C-C motif) ligand 15 precursorHPRD03232
NP_001286.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1230CCR1_HUMANP32246IPR000248Angtn2_rcptAngiotensin II receptor
1230CCR1_HUMANP32246IPR000190AT1_rcptAT1 angiotensin II receptor
1230CCR1_HUMANP32246IPR002236CC_1_rcptC-C chemokine receptor, type 1
1230CCR1_HUMANP32246IPR002238CC_3_rcptC-C chemokine receptor, type 3
1230CCR1_HUMANP32246IPR002240CC_5_rcptC-C chemokine receptor, type 5
1230CCR1_HUMANP32246IPR000355Chmkine_rcptChemokine receptor
1230CCR1_HUMANP32246IPR001277CXC_4_rcptC-X-C chemokine receptor, type 4
1230CCR1_HUMANP32246IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1230CCR1_HUMANP32246IPR000611NPY_rcptNeuropeptide Y receptor
1230CCR1_HUMANP32246IPR002286P2_purnocptorP2 purinoceptor

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.