Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1234
Official Symbol:CCR5
Other Aliases:CC-CKR-5|CCCKR5|CD195|CKR-5|CKR5|CMKBR5
See related:HGNC:1606|MIM:601373|HPRD:03223
Chromosome:3
Location:3p21
Gene Description:chemokine (C-C motif) receptor 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0361
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12774
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0270
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:10887175
Addiction Drug:OPIOIDS
Addiction Drug Detail:Morphine treatment causes CEM x174 cells to be more susceptible to SIV infection
Addiction Brain Area:CEM x174 cells
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0271
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:12500113
Addiction Drug:ALCOHOL
Addiction Drug Detail:Alcohol upregulate CCR5 receptor expression
Addiction Brain Area:Human blood monocyte-derived macrophages
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0273
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:12726730
Addiction Drug:OPIOINS
Addiction Drug Detail:Morphine enhances CXCR4 and CCR5 expression and subsequently increases both X4 and R5 HIV-1 infection
Addiction Brain Area:CD3(+) lymphoblasts and CD14(+) monocytes
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:HOT0234
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 6
KARG ID:HOT0044
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 7
KARG ID:HOT0199
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 8
KARG ID:HOT0196
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 9
KARG ID:HOT0289
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 10
KARG ID:HOT0235
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 11
KARG ID:HOT0233
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 12
KARG ID:HOT0318
ORGANISM:human
Entrez Gene ID:1234
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1234GO:0001584IEAFunctionrhodopsin-like receptor activity
1234GO:0004435TASFunctionphosphoinositide phospholipase C activity
1234GO:0005768TASComponentendosome
1234GO:0005886TASComponentplasma membrane
1234GO:0005887TASComponentintegral to plasma membrane
1234GO:0006935TASProcesschemotaxis
1234GO:0006954TASProcessinflammatory response
1234GO:0006968TASProcesscellular defense response
1234GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
1234GO:0007204TASProcesselevation of cytosolic calcium ion concentration
1234GO:0007267TASProcesscell-cell signaling
1234GO:0009986IDAComponentcell surface
1234GO:0015026TASFunctioncoreceptor activity
1234GO:0016493NASFunctionC-C chemokine receptor activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6354CAA50405.1monocyte chemoattractant protein (MCP-3)HPRD01150
-6347NP_002973.1small inducible cytokine A2 precursorHPRD01149
-6348NP_002974.1chemokine (C-C motif) ligand 3HPRD01656
-6351NP_002975.1chemokine C-C motif ligand 4 isoform 1 precursorHPRD01657
-6356NP_002977.1small inducible cytokine A11 precursorHPRD03098
-7294NP_003319.1TXK tyrosine kinaseHPRD02505
-7852NP_003458.1chemokine (C-X-C motif) receptor 4 isoform bHPRD01217
-2185NP_004094.3PTK2B protein tyrosine kinase 2 beta isoform aHPRD03131
-6357NP_005399.1small inducible cytokine A13 precursorHPRD03230
-5747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
-6358NP_116738.1chemokine (C-C motif) ligand 14 isoform 2 precursorHPRD03231
NP_000570.1--DynaminHPRD03223
NP_000570.1--AGPHPRD03223
NP_000570.12185-Focal adhesion kinase 2HPRD03223
NP_000570.15747-FAKHPRD03223
NP_000570.16347-Monocyte chemotactic protein 1HPRD03223
NP_000570.16354-Monocyte chemotactic protein 3HPRD03223
NP_000570.16357-Monocyte chemotactic protein 4HPRD03223
NP_000570.16358-CCL14HPRD03223
NP_000570.16356-CCL11HPRD03223
NP_000570.16348-CCL3HPRD03223
NP_000570.17294-Protein tyrosine kinase TXKHPRD03223
NP_000570.16351-CCL4HPRD03223
NP_000570.17852-CXCR4HPRD03223
NP_000570.1414062NP_001001437.1chemokine (C-C motif) ligand 3-like 3 precursorHPRD14426
NP_000570.16352NP_002976.2small inducible cytokine A5 precursorHPRD01751
NP_000570.16352NP_002976.2small inducible cytokine A5 precursorHPRD03223
NP_000570.16360NP_004581.1small inducible cytokine A16 precursorHPRD03223
NP_000570.16360NP_004581.1small inducible cytokine A16 precursorHPRD03233
NP_000570.13717NP_004963.1Janus kinase 2HPRD03223
NP_000570.13717NP_004963.1Janus kinase 2HPRD00993
NP_000570.13932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD03223
NP_000570.13932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD01080
NP_000570.16355NP_005614.2small inducible cytokine A8 precursorHPRD03791
NP_000570.16355NP_005614.2small inducible cytokine A8 precursorHPRD03223
NP_000570.16349NP_066286.1chemokine (C-C motif) ligand 3-like 1 precursorHPRD03234
NP_000570.16349NP_066286.1chemokine (C-C motif) ligand 3-like 1 precursorHPRD03223
NP_000570.1155871NP_057853.1Tat--
NP_000570.1155871NP_057853.1Tat--
NP_000570.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1234CCR5_HUMANP51681IPR000248Angtn2_rcptAngiotensin II receptor
1234CCR5_HUMANP51681IPR000190AT1_rcptAT1 angiotensin II receptor
1234CCR5_HUMANP51681IPR002236CC_1_rcptC-C chemokine receptor, type 1
1234CCR5_HUMANP51681IPR002238CC_3_rcptC-C chemokine receptor, type 3
1234CCR5_HUMANP51681IPR002240CC_5_rcptC-C chemokine receptor, type 5
1234CCR5_HUMANP51681IPR002237CC_chemok_rcpt_2C-C chemokine receptor, type 2
1234CCR5_HUMANP51681IPR000355Chmkine_rcptChemokine receptor
1234CCR5_HUMANP51681IPR001277CXC_4_rcptC-X-C chemokine receptor, type 4
1234CCR5_HUMANP51681IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1234CCR5_HUMANP51681IPR003912Protea_act_rcptProtease-activated receptor

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