Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1235
Official Symbol:CCR6
Other Aliases:BN-1|CD196|CKR-L3|CKR6|CKRL3|CMKBR6|DCR2|DRY-6|GPR-CY4|GPR29|GPRCY4|STRL22
See related:HGNC:1607|MIM:601835|HPRD:03498
Chromosome:6
Location:6q27
Gene Description:chemokine (C-C motif) receptor 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0056
ORGANISM:human
Entrez Gene ID:1235
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12458
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
75296CBCerebellum8.612120628356939.20146751403809
75296CTXCerebral cortex6.86639690399174.61503171920776
75296HIPHippocampal region3.592679262161252.97100973129272
75296HPFHippocampal formation3.146449089050292.42373657226562
75296HYHypothalamus1.134930133819580.86313784122467
75296LSXLateral septal complex0.9770590662956241.97779548168182
75296MBMidbrain5.431583404541026.21308183670044
75296MYMedulla10.418036460876511.004542350769
75296OLFOlfactory bulb8.264878273010255.44209480285645
75296PPons7.351601123809818.23148059844971
75296PALPallidum3.916442871093753.39405822753906
75296RHPRetrohippocampal region2.237216711044311.55187451839447
75296sAMYStriatum-like amygdalar nuclei2.343660593032841.80871307849884
75296STRStriatum1.132345080375670.957938730716705
75296STRdStriatum dorsal region0.9437183737754820.713968575000763
75296STRvStriatum ventral region1.240605235099790.872075319290161
75296THThalamus5.163961410522463.77238249778748
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1235GO:0001584IEAFunctionrhodopsin-like receptor activity
1235GO:0004872TASFunctionreceptor activity
1235GO:0004945IEAFunctionangiotensin type II receptor activity
1235GO:0005886TASComponentplasma membrane
1235GO:0005887TASComponentintegral to plasma membrane
1235GO:0006928TASProcesscell motility
1235GO:0006935TASProcesschemotaxis
1235GO:0006959TASProcesshumoral immune response
1235GO:0006968TASProcesscellular defense response
1235GO:0007165TASProcesssignal transduction
1235GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
1235GO:0007204TASProcesselevation of cytosolic calcium ion concentration
1235GO:0016493IEAFunctionC-C chemokine receptor activity
1235GO:0019735TASProcessantimicrobial humoral response (sensu Vertebrata)
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6364NP_004582.1chemokine (C-C motif) ligand 20HPRD03571
-1673NP_004933.1defensin, beta 4 precursorHPRD03739
-55894NP_061131.1defensin, beta 103A precursorHPRD05968
NP_004358.26364-Macrophage inflammatory protein 3 alphaHPRD03498
NP_004358.21673-Defensin, beta 4HPRD03498
NP_004358.255894-Defensin, beta 103HPRD03498
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1235CCR6_HUMANP51684IPR000190AT1_rcptAT1 angiotensin II receptor
1235CCR6_HUMANP51684IPR005383CC_11_rcptC-C chemokine receptor, type 11
1235CCR6_HUMANP51684IPR004067CC_6_rcptC-C chemokine receptor, type 6
1235CCR6_HUMANP51684IPR001718CC_7_rcptC-C chemokine receptor, type 7
1235CCR6_HUMANP51684IPR000355Chmkine_rcptChemokine receptor
1235CCR6_HUMANP51684IPR001277CXC_4_rcptC-X-C chemokine receptor, type 4
1235CCR6_HUMANP51684IPR005384Duffy_cmk_rcptDuffy antigen/chemokine receptor
1235CCR6_HUMANP51684IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1235CCR6_HUMANP51684IPR000174IL8_rcptInterleukin-8 receptor
1235CCR6_HUMANP51684IPR002286P2_purnocptorP2 purinoceptor

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