Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1267
Official Symbol:CNP
Other Aliases:CNP1
See related:HGNC:2158|MIM:123830|HPRD:00448
Chromosome:17
Location:17q21
Gene Description:2',3'-cyclic nucleotide 3' phosphodiesterase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0530
ORGANISM:human
Entrez Gene ID:1267
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25275
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0161
ORGANISM:human
Entrez Gene ID:1267
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:superior frontal gyrus
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 3
KARG ID:EVIM0166
ORGANISM:human
Entrez Gene ID:1267
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 4
KARG ID:EVIM0832
ORGANISM:human
Entrez Gene ID:1267
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.7 :: -2.5
KARG Evidence 5
KARG ID:EVIM0833
ORGANISM:human
Entrez Gene ID:1267
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: 1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12799CBCerebellum92.726634979248100.0
12799CTXCerebral cortex67.799867630004972.0622653961182
12799HIPHippocampal region54.390716552734478.3058929443359
12799HPFHippocampal formation63.620811462402382.4311370849609
12799HYHypothalamus100.0100.0
12799LSXLateral septal complex79.290676116943493.6452941894531
12799MBMidbrain100.0100.0
12799MYMedulla100.0100.0
12799OLFOlfactory bulb73.928665161132874.4310111999512
12799PPons100.0100.0
12799PALPallidum100.0100.0
12799RHPRetrohippocampal region79.701747894287188.456470489502
12799sAMYStriatum-like amygdalar nuclei67.99353790283271.186393737793
12799STRStriatum80.264484405517691.8216934204102
12799STRdStriatum dorsal region85.9023895263672100.0
12799STRvStriatum ventral region67.683620452880965.5107097625732
12799THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1267GO:0004113TASFunction2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
1267GO:0007268TASProcesssynaptic transmission
1267GO:0009214IEAProcesscyclic nucleotide catabolism
1267GO:0016020IEAComponentmembrane
1267GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7846NP_006000.2tubulin, alpha 3HPRD03959
NP_149124.17846-Tubulin, alpha, brain specificHPRD00448
NP_149124.2155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1267CN37_HUMANP09543IPR008431CNPaseCyclic nucleotide phosphodiesterase

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