Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1268
Official Symbol:CNR1
Other Aliases:CANN6|CB-R|CB1|CB1A|CB1K5|CNR
See related:HGNC:2159|MIM:114610|HPRD:00259
Chromosome:6
Location:6q14-q15
Gene Description:cannabinoid receptor 1 (brain)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0230
ORGANISM:human
Entrez Gene ID:1268
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12801
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0441
ORGANISM:human
Entrez Gene ID:1268
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25248
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0124
ORGANISM:human
Entrez Gene ID:1268
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15289816
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0209
ORGANISM:human
Entrez Gene ID:1268
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16314880
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12801CBCerebellum100.0100.0
12801CTXCerebral cortex100.0100.0
12801HIPHippocampal region65.3541831970215100.0
12801HPFHippocampal formation81.3203659057617100.0
12801HYHypothalamus98.4414558410645100.0
12801LSXLateral septal complex100.0100.0
12801MBMidbrain83.897583007812593.3282432556152
12801MYMedulla79.685333251953198.686092376709
12801OLFOlfactory bulb91.7184867858887100.0
12801PPons59.312477111816471.6273040771484
12801PALPallidum85.4060478210449100.0
12801RHPRetrohippocampal region99.1831817626953100.0
12801sAMYStriatum-like amygdalar nuclei89.984817504882897.0020790100098
12801STRStriatum100.0100.0
12801STRdStriatum dorsal region100.0100.0
12801STRvStriatum ventral region76.322807312011790.1876029968262
12801THThalamus25.478652000427229.8129501342773
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1268GO:0004872IEAFunctionreceptor activity
1268GO:0004949TASFunctioncannabinoid receptor activity
1268GO:0005886TASComponentplasma membrane
1268GO:0005887TASComponentintegral to plasma membrane
1268GO:0007165IEAProcesssignal transduction
1268GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
1268GO:0007610TASProcessbehavior
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3061NP_001516.1orexin receptor 1HPRD03863
NC_000006.9-AAC50053.1Human PAX3/forkhead transcription factor gene fusion mRNA, and translated productsBIND217823
NC_000006.95077--BIND217794
NC_000006.9121504NP_778224.1histone H4BIND217793
NP_057167.13061-Hypocretin receptor 1HPRD00259
NP_057167.12769NP_002059.1guanine nucleotide binding protein (G protein), alpha 15 (Gq class)HPRD00760
NP_057167.12769NP_002059.1guanine nucleotide binding protein (G protein), alpha 15 (Gq class)HPRD00259
NP_057167.12770NP_002060.3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1HPRD00756
NP_057167.12770NP_002060.3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1HPRD00259
NP_057167.12771NP_002061.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2HPRD00764
NP_057167.12771NP_002061.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2HPRD00259
NP_057167.12773NP_006487.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3HPRD00765
NP_057167.12773NP_006487.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3HPRD00259
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1268IPR002230Cnbnoid_rcptCannabinoid receptor
1268IPR000810Cnoid_rcpt_1Cannabinoid receptor, type 1
1268IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1268IPR000725Olfact_rcptOlfactory receptor
1268IPR008365Prostanoid_rcptProstanoid receptor
1268CNR1_HUMANP21554IPR002230Cnbnoid_rcptCannabinoid receptor
1268CNR1_HUMANP21554IPR000810Cnoid_rcpt_1Cannabinoid receptor, type 1
1268CNR1_HUMANP21554IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1268CNR1_HUMANP21554IPR008365Prostanoid_rcptProstanoid receptor

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