Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1278
Official Symbol:COL1A2
Other Aliases:OI4
See related:HGNC:2198|MIM:120160|HPRD:00363
Chromosome:7
Location:7q22.1
Gene Description:collagen, type I, alpha 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0255
ORGANISM:human
Entrez Gene ID:1278
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12843
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12843CBCerebellum27.310565948486348.0746269226074
12843CTXCerebral cortex30.195976257324218.3404331207275
12843HIPHippocampal region17.18054962158226.3515663146973
12843HPFHippocampal formation21.059701919555729.1430950164795
12843HYHypothalamus9.496261596679695.8980278968811
12843LSXLateral septal complex12.500791549682618.2492504119873
12843MBMidbrain14.613855361938516.3347320556641
12843MYMedulla18.856557846069318.6922168731689
12843OLFOlfactory bulb15.369974136352513.9737110137939
12843PPons17.010850906372121.069637298584
12843PALPallidum10.00296783447278.84017562866211
12843RHPRetrohippocampal region27.446111679077132.8416786193848
12843sAMYStriatum-like amygdalar nuclei22.914663314819317.7339153289795
12843STRStriatum8.594106674194347.27180624008179
12843STRdStriatum dorsal region5.980952739715584.37773990631104
12843STRvStriatum ventral region8.93567466735846.40152597427368
12843THThalamus12.845035552978512.6244659423828
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1278GO:0000004NDProcessbiological process unknown
1278GO:0001501TASProcessskeletal development
1278GO:0005201IEAFunctionextracellular matrix structural constituent
1278GO:0005201NASFunctionextracellular matrix structural constituent
1278GO:0005581IEAComponentcollagen
1278GO:0005584NRComponentcollagen type I
1278GO:0005584TASComponentcollagen type I
1278GO:0005737IEAComponentcytoplasm
1278GO:0006817IEAProcessphosphate transport
1278GO:0007169NASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
1278GO:0007605IEAProcesssensory perception of sound
1278GO:0008147NRFunctionstructural constituent of bone
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000080.1--AlphaV beta nHPRD00363
NP_000080.1--oxLDLHPRD00363
NP_000080.1--Platelet nonintegrin type I collagen receptorHPRD00363
NP_000080.17045NP_000349.1transforming growth factor, beta-induced, 68kDaHPRD00363
NP_000080.17045NP_000349.1transforming growth factor, beta-induced, 68kDaHPRD03409
NP_000080.13674NP_000410.1integrin alpha 2b precursorHPRD06377
NP_000080.13674NP_000410.1integrin alpha 2b precursorHPRD00363
NP_000080.17450NP_000543.1von Willebrand factor precursorHPRD00363
NP_000080.17450NP_000543.1von Willebrand factor precursorHPRD01906
NP_000080.15034NP_000909.2prolyl 4-hydroxylase, beta subunitHPRD00363
NP_000080.15034NP_000909.2prolyl 4-hydroxylase, beta subunitHPRD07181
NP_000080.11634NP_001911.1decorin isoform a preproproteinHPRD00501
NP_000080.11634NP_001911.1decorin isoform a preproproteinHPRD00363
NP_000080.12335NP_002017.1fibronectin 1 isoform 3 preproproteinHPRD00363
NP_000080.12335NP_002017.1fibronectin 1 isoform 3 preproproteinHPRD00626
NP_000080.13673NP_002194.1integrin alpha 2 precursorHPRD00363
NP_000080.13673NP_002194.1integrin alpha 2 precursorHPRD01893
NP_000080.14060NP_002336.1lumican precursorHPRD00363
NP_000080.14060NP_002336.1lumican precursorHPRD02793
NP_000080.16678NP_003109.1secreted protein, acidic, cysteine-rich (osteonectin)HPRD00363
NP_000080.16678NP_003109.1secreted protein, acidic, cysteine-rich (osteonectin)HPRD01631
NP_000080.14318NP_004985.1matrix metalloproteinase 9 preproproteinHPRD00363
NP_000080.14318NP_004985.1matrix metalloproteinase 9 preproproteinHPRD00387
NP_000080.122918NP_036204.1complement component 1, q subcomponent, receptor 1HPRD00396
NP_000080.122918NP_036204.1complement component 1, q subcomponent, receptor 1HPRD00363
NP_000080.150509NP_056534.1collagen, type V, alpha 3 preproproteinHPRD00369
NP_000080.150509NP_056534.1collagen, type V, alpha 3 preproproteinHPRD00363
NP_000080.1155871NP_057853.1Tat--
NP_000080.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1278CO1A2_HUMANP08123IPR008160CollagenCollagen triple helix repeat
1278CO1A2_HUMANP08123IPR000885Fib_collagen_CFibrillar collagen, C-terminal
1278CO1A2_HUMANP08123IPR000694PRO_richProline-rich region

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