Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:13
Official Symbol:AADAC
Other Aliases:DAC
See related:HGNC:17|MIM:600338|HPRD:02640
Chromosome:3
Location:3q21.3-q25.2
Gene Description:arylacetamide deacetylase (esterase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0260
ORGANISM:human
Entrez Gene ID:13
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.54
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
67758CBCerebellum0.00.0
67758CTXCerebral cortex0.00.0
67758HIPHippocampal region0.00.0
67758HPFHippocampal formation0.00.0
67758HYHypothalamus0.00.0
67758LSXLateral septal complex0.00.0
67758MBMidbrain0.00.0
67758MYMedulla0.00.0
67758OLFOlfactory bulb0.00.0
67758PPons0.00.0
67758PALPallidum0.00.0
67758RHPRetrohippocampal region0.00.0
67758sAMYStriatum-like amygdalar nuclei0.00.0
67758STRStriatum0.00.0
67758STRdStriatum dorsal region0.00.0
67758STRvStriatum ventral region0.00.0
67758THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
13GO:0005789IDAComponentendoplasmic reticulum membrane
13GO:0005792TASComponentmicrosome
13GO:0008152IEAProcessmetabolism
13GO:0016020IEAComponentmembrane
13GO:0016021IEAComponentintegral to membrane
13GO:0016298TASFunctionlipase activity
13GO:0019213IDAFunctiondeacetylase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
13AAAD_HUMANP22760IPR013094AB_hydrolase_3Alpha/beta hydrolase fold-3
13AAAD_HUMANP22760IPR002168Lipolytic_enzymeLipolytic enzyme
13AAAD_HUMANP22760IPR000379Ser_estrsEsterase/lipase/thioesterase

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