Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:130
Official Symbol:ADH6
Other Aliases:ADH-5
See related:HGNC:255|MIM:103735|HPRD:00067
Chromosome:4
Location:4q23
Gene Description:alcohol dehydrogenase 6 (class V)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0259
ORGANISM:human
Entrez Gene ID:130
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.54
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
229871CBCerebellum0.8436325788497921.13004040718079
69117CBCerebellum12.428464889526416.7738437652588
229871CTXCerebral cortex0.3256778717041020.386641710996628
69117CTXCerebral cortex53.728744506835937.7594566345215
229871HIPHippocampal region0.1734779030084610.208041220903397
69117HIPHippocampal region24.79475021362329.5455303192139
229871HPFHippocampal formation0.2719710469245910.46126052737236
69117HPFHippocampal formation24.510292053222724.1010246276855
229871HYHypothalamus0.04103607684373860.0251606348901987
69117HYHypothalamus5.473145484924324.14254426956177
229871LSXLateral septal complex0.03595333546400070.0
69117LSXLateral septal complex10.42190837860117.73149728775024
229871MBMidbrain0.3771930932998660.440138697624207
69117MBMidbrain3.41401457786563.16419363021851
229871MYMedulla2.132166862487792.4942102432251
69117MYMedulla4.424416065216064.02078008651733
229871OLFOlfactory bulb0.7800370454788211.94065546989441
69117OLFOlfactory bulb32.602664947509823.6186866760254
229871PPons0.4679849147796630.553313076496124
69117PPons1.61621320247651.57906901836395
229871PALPallidum0.1951058357954030.41415536403656
69117PALPallidum6.958502292633065.27957820892334
229871RHPRetrohippocampal region0.403921306133270.728029012680054
69117RHPRetrohippocampal region24.682191848754917.5711154937744
229871sAMYStriatum-like amygdalar nuclei0.03420099988579750.0
69117sAMYStriatum-like amygdalar nuclei5.564036369323733.70114159584045
229871STRStriatum0.07322728633880620.103592492640018
69117STRStriatum10.32471656799327.24164247512817
229871STRdStriatum dorsal region0.094528354704380.153268352150917
69117STRdStriatum dorsal region7.973247528076175.81154775619507
229871STRvStriatum ventral region0.03381144627928730.0200039111077785
69117STRvStriatum ventral region21.964321136474613.5666522979736
229871THThalamus0.2428548336029050.189180076122284
69117THThalamus4.683079719543463.90156865119934
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
130GO:0004022IEAFunctionalcohol dehydrogenase activity
130GO:0004022TASFunctionalcohol dehydrogenase activity
130GO:0006069TASProcessethanol oxidation
130GO:0008270IEAFunctionzinc ion binding
130GO:0016491IEAFunctionoxidoreductase activity
130GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
130ADH6_HUMANP28332IPR013154ADH_NAlcohol dehydrogenase GroES-like
130ADH6_HUMANP28332IPR002328ADH_ZnAlcohol dehydrogenase, zinc-containing
130ADH6_HUMANP28332IPR013149ADH_Zn_bdAlcohol dehydrogenase, zinc-binding

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