Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1325
Official Symbol:CORT
Other Aliases:CST-14|CST-17|CST-29
See related:HGNC:2257|MIM:602784|HPRD:04150
Chromosome:1
Location:1p36|1p36.22
Gene Description:cortistatin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0085
ORGANISM:human
Entrez Gene ID:1325
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
69928CBCerebellum1.69451963901522.59490847587585
12854CBCerebellum5.144459605216985.68323612213135
69928CTXCerebral cortex1.043565869331361.09666931629181
12854CTXCerebral cortex13.804917812347413.5201361179352
69928HIPHippocampal region1.788143634796142.20889663696289
12854HIPHippocampal region9.5742952823638913.7302303314209
69928HPFHippocampal formation1.41976439952851.53176140785217
12854HPFHippocampal formation10.528406620025613.0052690505981
69928HYHypothalamus0.1994421780109410.201884463429451
12854HYHypothalamus0.8952613323926930.658762365579605
69928LSXLateral septal complex0.2052930146455760.159324958920479
12854LSXLateral septal complex2.749837517738342.56075569987297
69928MBMidbrain0.4968277513980870.501274466514587
12854MBMidbrain4.014055728912353.46964484453201
12854MYMedulla2.633238554000852.59134960174561
69928MYMedulla2.985273122787484.01566791534424
69928OLFOlfactory bulb0.5879482030868530.474724948406219
12854OLFOlfactory bulb8.495766758918767.16915214061737
69928PPons1.370997190475461.40119552612305
12854PPons2.901149630546572.86432504653931
12854PALPallidum1.353371173143391.07332183420658
69928PALPallidum1.491785526275631.31091439723969
69928RHPRetrohippocampal region0.7200934886932370.492251425981522
12854RHPRetrohippocampal region11.548953056335411.3642454147339
69928sAMYStriatum-like amygdalar nuclei0.3691422045230870.372972100973129
12854sAMYStriatum-like amygdalar nuclei1.088441401720051.09731814265251
69928STRStriatum0.6919699907302860.516847848892212
12854STRStriatum1.247600197792051.52132219076157
69928STRdStriatum dorsal region0.9096438884735110.684866070747375
12854STRdStriatum dorsal region1.048256546258931.54684150218964
69928STRvStriatum ventral region0.4584394395351410.307900846004486
12854STRvStriatum ventral region1.292058736085891.20620158314705
69928THThalamus1.531935572624211.59919345378876
12854THThalamus3.285607680678372.54491594433784
KARG Evidence 2
KARG ID:QTL0085
Trait:alcohol preference
Peak:81
Peak Marker:D4Mit42
Parents:(C57BL/6J x DBA/2J)F2 intercross
Evidence ID:9726281
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1325GO:0001664IPIFunctionG-protein-coupled receptor binding
1325GO:0005184TASFunctionneuropeptide hormone activity
1325GO:0005576IEAComponentextracellular region
1325GO:0005625TASComponentsoluble fraction
1325GO:0007193TASProcessG-protein signaling, adenylate cyclase inhibiting pathway
1325GO:0007268TASProcesssynaptic transmission
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2693NP_940799.1growth hormone secretagogue receptor isoform 1aHPRD03541
NP_001293.12693-Growth hormone secretagogue receptorHPRD04150
NP_001293.16751NP_001040.1somatostatin receptor 1HPRD01673
NP_001293.16751NP_001040.1somatostatin receptor 1HPRD04150
NP_001293.16752NP_001041.1somatostatin receptor 2HPRD01674
NP_001293.16752NP_001041.1somatostatin receptor 2HPRD04150
NP_001293.16753NP_001042.1somatostatin receptor 3HPRD01675
NP_001293.16753NP_001042.1somatostatin receptor 3HPRD04150
NP_001293.16754NP_001043.1somatostatin receptor 4HPRD01676
NP_001293.16754NP_001043.1somatostatin receptor 4HPRD04150
NP_001293.16755NP_001044.1somatostatin receptor 5HPRD01677
NP_001293.16755NP_001044.1somatostatin receptor 5HPRD04150
NP_001293.1117194NP_473371.1MAS-related GPR, member X2HPRD06247
NP_001293.1117194NP_473371.1MAS-related GPR, member X2HPRD04150
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1325CORT_HUMANO00230IPR004250SomatostatinSomatostatin/Cortistatin

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