Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:133
Official Symbol:ADM
Other Aliases:AM
See related:HGNC:259|MIM:103275|HPRD:00061
Chromosome:11
Location:11p15.4
Gene Description:adrenomedullin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIP0209
ORGANISM:human
Entrez Gene ID:133
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.42
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11535CBCerebellum0.685862779617311.50496864318848
11535CTXCerebral cortex1.852301239967351.65131425857544
11535HIPHippocampal region0.7415346503257750.789429098367691
11535HPFHippocampal formation1.005213946104051.03757387399673
11535HYHypothalamus2.0060728713873.8381137624383
11535LSXLateral septal complex0.1942161973565820.182867035269737
11535MBMidbrain1.225322902202611.72531086206436
11535MYMedulla2.275935530662544.02039861679077
11535OLFOlfactory bulb4.629318356513984.43894416093826
11535PPons3.628297686576846.20740211009979
11535PALPallidum0.4055810421705250.942235924303532
11535RHPRetrohippocampal region1.488042920827871.40820083022118
11535sAMYStriatum-like amygdalar nuclei0.7155767083168031.21416267007589
11535STRStriatum0.4931825846433640.622312918305397
11535STRdStriatum dorsal region0.3418140560388570.251634478569031
11535STRvStriatum ventral region0.928855106234551.45344656705856
11535THThalamus2.386902868747712.20208722352982
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
133GO:0005179IEAFunctionhormone activity
133GO:0005615TASComponentextracellular space
133GO:0005625TASComponentsoluble fraction
133GO:0006171TASProcesscAMP biosynthesis
133GO:0006701TASProcessprogesterone biosynthesis
133GO:0007165TASProcesssignal transduction
133GO:0007267TASProcesscell-cell signaling
133GO:0007565TASProcesspregnancy
133GO:0007588NRProcessexcretion
133GO:0008015TASProcesscirculation
133GO:0009611TASProcessresponse to wounding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-11318NP_009195.1adrenomedullin receptorHPRD05605
NP_001115.1--CRLRHPRD00061
NP_001115.111318-Adrenomedullin receptorHPRD00061
NP_001115.13075NP_000177.1complement factor HHPRD00061
NP_001115.13075NP_000177.1complement factor HHPRD00601
NP_001115.11906NP_001946.2endothelin 1HPRD00061
NP_001115.11906NP_001946.2endothelin 1HPRD07030
NP_001115.110203NP_005786.1calcitonin receptor-likeHPRD11809
NP_001115.14880NP_077720.1natriuretic peptide precursor CHPRD08975
NP_001115.14880NP_077720.1natriuretic peptide precursor CHPRD00061
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
133ADML_HUMANP35318IPR001710AdrenomedullinAdrenomedullin

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