Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1345
Official Symbol:COX6C
Other Aliases:-
See related:HGNC:2285|MIM:124090|HPRD:00494
Chromosome:8
Location:8q22-q23
Gene Description:cytochrome c oxidase subunit VIc
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0100
ORGANISM:human
Entrez Gene ID:1345
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12864
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0099
ORGANISM:human
Entrez Gene ID:1345
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.40 :: 2.60 :: 2.23 :: 2.35 :: -0.71 :: -1.99 :: -0.51
KARG Evidence 3
KARG ID:EVIM0950
ORGANISM:human
Entrez Gene ID:1345
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12864CBCerebellum29.532817840576255.965970993042
12864CTXCerebral cortex86.544555664062585.1453742980957
12864HIPHippocampal region60.411645889282288.807559967041
12864HPFHippocampal formation68.448093414306686.7363548278809
12864HYHypothalamus39.845598220825240.3422889709473
12864LSXLateral septal complex27.735756874084522.6263327598572
12864MBMidbrain56.893585205078169.3784999847412
12864MYMedulla60.729616165161195.6862030029297
12864OLFOlfactory bulb63.570652008056663.6511554718018
12864PPons63.057565689086989.494327545166
12864PALPallidum43.261106491088955.1882171630859
12864RHPRetrohippocampal region81.261188507080185.1458129882812
12864sAMYStriatum-like amygdalar nuclei35.6844377517733.9004421234131
12864STRStriatum27.685249328613325.0148134231567
12864STRdStriatum dorsal region25.735127449035623.6062746047974
12864STRvStriatum ventral region30.467506408691425.4604454040527
12864THThalamus60.380342483520568.1911029815674
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1345GO:0004129IEAFunctioncytochrome-c oxidase activity
1345GO:0005739IEAComponentmitochondrion
1345GO:0006118IEAProcesselectron transport
1345GO:0016020IEAComponentmembrane
1345GO:0016021IEAComponentintegral to membrane
1345GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1345COX6C_HUMANP09669IPR004204COX6CCytochrome c oxidase subunit VIc

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