Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:134526
Official Symbol:ACOT12
Other Aliases:CACH-1|Cach|MGC105114|STARD15|THEAL
See related:HGNC:24436|HPRD:16680
Chromosome:5
Location:5q14.1
Gene Description:acyl-CoA thioesterase 12
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0265
ORGANISM:human
Entrez Gene ID:134526
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.60
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
74156CBCerebellum3.367445945739755.98161458969116
74156CTXCerebral cortex0.4953095614910130.52610582113266
74156HIPHippocampal region0.2944277822971340.334770500659943
74156HPFHippocampal formation0.2619878351688390.276991248130798
74156HYHypothalamus0.3348526656627660.202837139368057
74156LSXLateral septal complex0.2396911233663560.276043295860291
74156MBMidbrain0.3866276741027830.388190001249313
74156MYMedulla1.372319579124452.10232138633728
74156OLFOlfactory bulb1.200190186500550.810807228088379
74156PPons0.3764121830463410.445054888725281
74156PALPallidum0.2430421710014340.363007813692093
74156RHPRetrohippocampal region0.1445454210042950.112106837332249
74156sAMYStriatum-like amygdalar nuclei0.3088808059692380.20026271045208
74156STRStriatum0.2281375378370290.205401107668877
74156STRdStriatum dorsal region0.1867964863777160.171037942171097
74156STRvStriatum ventral region0.2867353260517120.225958973169327
74156THThalamus1.80235338211062.28654408454895
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
134526GO:0003986ISSFunctionacetyl-CoA hydrolase activity
134526GO:0004759IEAFunctionserine esterase activity
134526GO:0005524ISSFunctionATP binding
134526GO:0005829ISSComponentcytosol
134526GO:0006629IEAProcesslipid metabolism
134526GO:0006637ISSProcessacyl-CoA metabolism
134526GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
134526ACO12_HUMANQ8WYK0IPR002913START_lipid_bdLipid-binding START
134526ACO12_HUMANQ8WYK0IPR006683Thioestr_supfThioesterase superfamily

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