Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1347
Official Symbol:COX7A2
Other Aliases:COX7AL|COX7AL1|COXVIIa-L|MGC118950|MGC118951|MGC118952|MGC126875|MGC126877
See related:HGNC:2288|MIM:123996|HPRD:00482
Chromosome:6
Location:6q12
Gene Description:cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0272
ORGANISM:human
Entrez Gene ID:1347
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.89
KARG Evidence 2
KARG ID:QTL0143
ORGANISM:human
Entrez Gene ID:1347
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:QTL0144
ORGANISM:human
Entrez Gene ID:1347
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12866CBCerebellum15.509831428527833.5228462219238
12866CTXCerebral cortex100.0100.0
12866HIPHippocampal region100.0100.0
12866HPFHippocampal formation100.0100.0
12866HYHypothalamus100.0100.0
12866LSXLateral septal complex100.0100.0
12866MBMidbrain56.033523559570383.7038497924805
12866MYMedulla30.101947784423865.1392974853516
12866OLFOlfactory bulb80.5506973266602100.0
12866PPons49.932231903076296.6488265991211
12866PALPallidum92.6677627563477100.0
12866RHPRetrohippocampal region94.6647033691406100.0
12866sAMYStriatum-like amygdalar nuclei100.0100.0
12866STRStriatum87.203018188476685.1019287109375
12866STRdStriatum dorsal region80.662918090820376.2776870727539
12866STRvStriatum ventral region68.747268676757867.2304153442383
12866THThalamus100.0100.0
KARG Evidence 4
KARG ID:QTL0143
Trait:cocaine related behaviol
Peak:42
Peak Marker:D9Ncvs47
Parents:BXD/Ty (B = C57BL/6, D = DBA/2) recombinant inbred
Evidence ID:10591541
KARG Evidence 5
KARG ID:QTL0144
Trait:morphine antinociception
Peak:42
Peak Marker:D9Mit8
Parents:C57BL/6J x DBA/2J)F2 intercross; BXD (B = C57BL/6J, D = DBA/2J) (RI)
Evidence ID:11420618
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1347GO:0004129IEAFunctioncytochrome-c oxidase activity
1347GO:0005739IEAComponentmitochondrion
1347GO:0006118IEAProcesselectron transport
1347GO:0016020IEAComponentmembrane
1347GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1347CX7A2_HUMANP14406IPR003177COX7aCytochrome c oxidase, subunit VIIa

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