Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1363
Official Symbol:CPE
Other Aliases:-
See related:HGNC:2303|MIM:114855|HPRD:00272
Chromosome:4
Location:4q32.3
Gene Description:carboxypeptidase E
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0250
ORGANISM:human
Entrez Gene ID:1363
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12876
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0201
ORGANISM:human
Entrez Gene ID:1363
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
KARG Evidence 3
KARG ID:EVIM0425
ORGANISM:human
Entrez Gene ID:1363
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.1 :: 1.2 :: 1.2 :: 1.1 :: -1.4 :: -1.5
KARG Evidence 4
KARG ID:EVIM0493
ORGANISM:human
Entrez Gene ID:1363
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.6 :: -1.2 :: 1.6 :: 1.3
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1363GO:0004180TASFunctioncarboxypeptidase activity
1363GO:0004182IEAFunctioncarboxypeptidase A activity
1363GO:0004183IEAFunctioncarboxypeptidase E activity
1363GO:0005886TASComponentplasma membrane
1363GO:0006464NASProcessprotein modification
1363GO:0006508IEAProcessproteolysis
1363GO:0007218NASProcessneuropeptide signaling pathway
1363GO:0008152TASProcessmetabolism
1363GO:0008237IEAFunctionmetallopeptidase activity
1363GO:0008270IEAFunctionzinc ion binding
1363GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2641NP_002045.1glucagon preproproteinHPRD00676
NP_001864.1--Pro-neurotensinHPRD00272
NP_001864.1--Pro-thyrotropin-releasing hormoneHPRD00272
NP_001864.15367-Pro melanin concentrating hormoneHPRD00272
NP_001864.12641-GlucagonHPRD00272
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1363CBPE_HUMANP16870IPR000834Peptidase_M14Peptidase M14, carboxypeptidase A

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